The article highlights significant public health achievements in the United States from 1900 to 1999, focusing on ten notable accomplishments. The first report in the series emphasizes the impact of vaccination, which has led to the eradication of smallpox, the elimination of poliomyelitis in the Americas, and the control of several other infectious diseases. Other achievements include improvements in motor-vehicle safety, which have significantly reduced motor-vehicle-related deaths. The article also details the decline in morbidity from nine vaccine-preventable diseases, including smallpox, polio, measles, and Hib invasive disease. Additionally, it discusses the implementation of a comprehensive tobacco prevention and education program in Oregon, which resulted in a substantial decline in cigarette consumption. These achievements underscore the effectiveness of public health interventions in improving health outcomes and reducing disease burden.The article highlights significant public health achievements in the United States from 1900 to 1999, focusing on ten notable accomplishments. The first report in the series emphasizes the impact of vaccination, which has led to the eradication of smallpox, the elimination of poliomyelitis in the Americas, and the control of several other infectious diseases. Other achievements include improvements in motor-vehicle safety, which have significantly reduced motor-vehicle-related deaths. The article also details the decline in morbidity from nine vaccine-preventable diseases, including smallpox, polio, measles, and Hib invasive disease. Additionally, it discusses the implementation of a comprehensive tobacco prevention and education program in Oregon, which resulted in a substantial decline in cigarette consumption. These achievements underscore the effectiveness of public health interventions in improving health outcomes and reducing disease burden.