The study investigates thalamocortical dysrhythmia, a neurological and neuropsychiatric syndrome characterized by increased low-frequency θ rhythmicity and coherence among high- and low-frequency oscillations. Magnetoencephalographic (MEG) recordings were conducted on healthy controls and patients with conditions such as neuropathic pain, tinnitus, Parkinson's disease, and depression. Patients showed enhanced θ activity and increased coherence, suggesting the presence of thalamocortical dysrhythmia. This coherent θ activity is attributed to low-threshold calcium spike bursts in thalamic cells, leading to hyperpolarization and the emergence of positive clinical symptoms through the "edge effect," where γ-band activation is ectopically generated. The study proposes that this dysrhythmia is a common mechanism underlying various neurological and psychiatric conditions, with its localization determining the specific symptoms. The findings support the use of MEG for diagnosing thalamocortical dysrhythmia and suggest combining MEG with PET and functional MRI for better understanding and treatment.The study investigates thalamocortical dysrhythmia, a neurological and neuropsychiatric syndrome characterized by increased low-frequency θ rhythmicity and coherence among high- and low-frequency oscillations. Magnetoencephalographic (MEG) recordings were conducted on healthy controls and patients with conditions such as neuropathic pain, tinnitus, Parkinson's disease, and depression. Patients showed enhanced θ activity and increased coherence, suggesting the presence of thalamocortical dysrhythmia. This coherent θ activity is attributed to low-threshold calcium spike bursts in thalamic cells, leading to hyperpolarization and the emergence of positive clinical symptoms through the "edge effect," where γ-band activation is ectopically generated. The study proposes that this dysrhythmia is a common mechanism underlying various neurological and psychiatric conditions, with its localization determining the specific symptoms. The findings support the use of MEG for diagnosing thalamocortical dysrhythmia and suggest combining MEG with PET and functional MRI for better understanding and treatment.