The β-catenin destruction complex is a multiprotein assembly that regulates the degradation of β-catenin, a key component of the Wnt signaling pathway. In the absence of Wnt signals, β-catenin is phosphorylated by kinases such as GSK-3 and CK1, leading to its ubiquitination and degradation by the proteasome. The complex includes Axin, APC, GSK-3, CK1, and β-TrCP, which work together to phosphorylate β-catenin and target it for degradation. Axin serves as a scaffold that brings together the kinases and β-catenin, facilitating efficient phosphorylation. APC, a tumor suppressor, plays a critical role in this process by interacting with Axin and β-catenin, and its mutations are associated with cancer. The phosphorylation of β-catenin by the complex is essential for its degradation, and the role of APC in this process remains an area of active research. The destruction complex is dynamic, and its components are involved in various cellular processes beyond Wnt signaling. Understanding the molecular mechanisms of the destruction complex is crucial for elucidating the regulation of Wnt signaling and its implications in development and disease.The β-catenin destruction complex is a multiprotein assembly that regulates the degradation of β-catenin, a key component of the Wnt signaling pathway. In the absence of Wnt signals, β-catenin is phosphorylated by kinases such as GSK-3 and CK1, leading to its ubiquitination and degradation by the proteasome. The complex includes Axin, APC, GSK-3, CK1, and β-TrCP, which work together to phosphorylate β-catenin and target it for degradation. Axin serves as a scaffold that brings together the kinases and β-catenin, facilitating efficient phosphorylation. APC, a tumor suppressor, plays a critical role in this process by interacting with Axin and β-catenin, and its mutations are associated with cancer. The phosphorylation of β-catenin by the complex is essential for its degradation, and the role of APC in this process remains an area of active research. The destruction complex is dynamic, and its components are involved in various cellular processes beyond Wnt signaling. Understanding the molecular mechanisms of the destruction complex is crucial for elucidating the regulation of Wnt signaling and its implications in development and disease.