The 2007 WHO Classification of Tumours of the Central Nervous System, published in 2007, introduces several new entities and variants, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituitary tumour, and spindle cell oncocytoma of the adenohypophysis. Histological variants were added based on evidence of different age distribution, location, genetic profile, or clinical behavior. The grading scheme and genetic profiles were updated, and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes involving the nervous system. The classification is based on the consensus of an international Working Group of 25 pathologists and geneticists, along with contributions from over 70 international experts. The classification is accompanied by concise commentaries on clinico-pathological characteristics of each tumour type.The 2007 WHO Classification of Tumours of the Central Nervous System, published in 2007, introduces several new entities and variants, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituitary tumour, and spindle cell oncocytoma of the adenohypophysis. Histological variants were added based on evidence of different age distribution, location, genetic profile, or clinical behavior. The grading scheme and genetic profiles were updated, and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes involving the nervous system. The classification is based on the consensus of an international Working Group of 25 pathologists and geneticists, along with contributions from over 70 international experts. The classification is accompanied by concise commentaries on clinico-pathological characteristics of each tumour type.