The article "The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry" published in the *International Journal of Nanomedicine* explores the use of silver nanoparticles in dentistry. Silver nanoparticles, due to their broad-spectrum antibacterial, antifungal, and antiviral properties, have gained attention for their potential in biomedical applications. These nanoparticles can penetrate bacterial cell walls, disrupt cell membranes, and inhibit DNA replication, leading to cell death. Their efficacy is attributed to their nanoscale size and large surface area-to-volume ratio. In dentistry, silver nanoparticles are used in various applications, including: - **Prosthetic Treatment**: Incorporating silver nanoparticles into acrylic resins for removable dentures to inhibit bacterial growth. - **Restorative Treatment**: Adding nanoparticles to composite resins to prevent secondary caries. - **Endodontic Treatment**: Using them as a substitute for sodium hypochlorite in irrigation solutions and as an antimicrobial obturator for root canal obturation. - **Orthodontic Treatment**: Preventing enamel caries and inhibiting biofilm growth on orthodontic materials. - **Dental Implant Treatment**: Enhancing the antibacterial properties of titanium implants to prevent peri-implant infections. - **Periodontal Treatment**: Improving infection control and reducing inflammation through their antibacterial and anti-inflammatory properties. Despite concerns about potential toxicity and environmental hazards, silver nanoparticles have shown promise in clinical settings. They are generally biocompatible and have low cytotoxicity, but further research is needed to fully understand their long-term effects. The article highlights the antibacterial mechanisms of silver nanoparticles, their applications in dentistry, and the ongoing efforts to ensure their safety.The article "The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry" published in the *International Journal of Nanomedicine* explores the use of silver nanoparticles in dentistry. Silver nanoparticles, due to their broad-spectrum antibacterial, antifungal, and antiviral properties, have gained attention for their potential in biomedical applications. These nanoparticles can penetrate bacterial cell walls, disrupt cell membranes, and inhibit DNA replication, leading to cell death. Their efficacy is attributed to their nanoscale size and large surface area-to-volume ratio. In dentistry, silver nanoparticles are used in various applications, including: - **Prosthetic Treatment**: Incorporating silver nanoparticles into acrylic resins for removable dentures to inhibit bacterial growth. - **Restorative Treatment**: Adding nanoparticles to composite resins to prevent secondary caries. - **Endodontic Treatment**: Using them as a substitute for sodium hypochlorite in irrigation solutions and as an antimicrobial obturator for root canal obturation. - **Orthodontic Treatment**: Preventing enamel caries and inhibiting biofilm growth on orthodontic materials. - **Dental Implant Treatment**: Enhancing the antibacterial properties of titanium implants to prevent peri-implant infections. - **Periodontal Treatment**: Improving infection control and reducing inflammation through their antibacterial and anti-inflammatory properties. Despite concerns about potential toxicity and environmental hazards, silver nanoparticles have shown promise in clinical settings. They are generally biocompatible and have low cytotoxicity, but further research is needed to fully understand their long-term effects. The article highlights the antibacterial mechanisms of silver nanoparticles, their applications in dentistry, and the ongoing efforts to ensure their safety.