Kaempferol, a natural compound found in fruits, vegetables, and plants, has gained attention for its potential anticancer properties. This systematic review, following PRISMA guidelines, analyzed 64 in vitro studies to evaluate the anticancer effects of kaempferol on various solid tumors. The results indicate that kaempferol exerts antitumor effects by controlling tumor cell cycle progression, proliferation, apoptosis, migration, and invasion. It also inhibits angiogenesis and modulates epithelial-mesenchymal transition (EMT) markers. Additionally, kaempferol enhances the sensitivity of cancer cells to chemotherapy drugs such as cisplatin and 5-fluorouracil. The review highlights the potential of kaempferol as a natural anticancer drug, particularly when combined with current anticancer agents. However, further research is needed to establish its exact mechanisms of action and to explore its clinical applications.Kaempferol, a natural compound found in fruits, vegetables, and plants, has gained attention for its potential anticancer properties. This systematic review, following PRISMA guidelines, analyzed 64 in vitro studies to evaluate the anticancer effects of kaempferol on various solid tumors. The results indicate that kaempferol exerts antitumor effects by controlling tumor cell cycle progression, proliferation, apoptosis, migration, and invasion. It also inhibits angiogenesis and modulates epithelial-mesenchymal transition (EMT) markers. Additionally, kaempferol enhances the sensitivity of cancer cells to chemotherapy drugs such as cisplatin and 5-fluorouracil. The review highlights the potential of kaempferol as a natural anticancer drug, particularly when combined with current anticancer agents. However, further research is needed to establish its exact mechanisms of action and to explore its clinical applications.