A systematic review of in vitro studies on kaempferol (KMP) reveals its potential as an anticancer agent. KMP, a flavonoid found in plants, exhibits anticancer effects by inhibiting tumor cell proliferation, migration, invasion, and angiogenesis. It promotes apoptosis, disrupts cell cycle progression, and enhances sensitivity to chemotherapy drugs such as cisplatin and 5-fluorouracil. KMP also modulates key signaling pathways, including MAPK, PI3K/Akt, and JNK, which are involved in cancer progression. Additionally, KMP inhibits epithelial-mesenchymal transition (EMT), a process that facilitates cancer metastasis. The compound has shown efficacy against various cancers, including breast, lung, ovarian, colon, liver, and pancreatic cancers. KMP's ability to sensitize cancer cells to chemotherapy and its low toxicity make it a promising candidate for cancer treatment. However, further research is needed to confirm its in vivo efficacy and to explore its mechanisms of action in more detail. The review highlights the need for clinical trials to evaluate KMP's potential as a therapeutic agent in cancer treatment.A systematic review of in vitro studies on kaempferol (KMP) reveals its potential as an anticancer agent. KMP, a flavonoid found in plants, exhibits anticancer effects by inhibiting tumor cell proliferation, migration, invasion, and angiogenesis. It promotes apoptosis, disrupts cell cycle progression, and enhances sensitivity to chemotherapy drugs such as cisplatin and 5-fluorouracil. KMP also modulates key signaling pathways, including MAPK, PI3K/Akt, and JNK, which are involved in cancer progression. Additionally, KMP inhibits epithelial-mesenchymal transition (EMT), a process that facilitates cancer metastasis. The compound has shown efficacy against various cancers, including breast, lung, ovarian, colon, liver, and pancreatic cancers. KMP's ability to sensitize cancer cells to chemotherapy and its low toxicity make it a promising candidate for cancer treatment. However, further research is needed to confirm its in vivo efficacy and to explore its mechanisms of action in more detail. The review highlights the need for clinical trials to evaluate KMP's potential as a therapeutic agent in cancer treatment.