The Arizona Sexual Experience Scale (ASEX) is a five-item rating scale designed to quantify sexual dysfunction, including sex drive, arousal, vaginal lubrication/penile erection, ability to reach orgasm, and satisfaction from orgasm. The scale ranges from 5 to 30, with higher scores indicating more sexual dysfunction. This study assesses the internal consistency, test-retest reliability, and convergent and discriminant validity of the ASEX. The ASEX demonstrated excellent internal consistency (Cronbach’s alpha = .9055) and strong test-retest reliability (for patients, r = .801, p < .01; for controls, r = .892, p < .01). The ASEX items correlated with the Brief Index of Sexual Functioning (BISF) factors and related items but not with depression scores. ANOVAs revealed significant differences in total ASEX scores between patients and controls, as well as between females and males. The sensitivity and specificity of the ASEX at identifying sexual dysfunction were 82% and 90%, respectively, with positive predictive value (PPV) of 88% and negative predictive value (NPV) of 85%. ROC analysis showed an AUC value of .929 ± .029 for the ASEX, significantly higher than the AUC value of .786 ± .050 for the BISF. The ASEX is a reliable and valid tool for measuring sexual dysfunction, offering advantages over more lengthy scales due to its simplicity, ease of scoring, and ability to quickly identify core elements of sexual dysfunction. However, the study had limitations, including a small sample size and the need for further validation in different populations.The Arizona Sexual Experience Scale (ASEX) is a five-item rating scale designed to quantify sexual dysfunction, including sex drive, arousal, vaginal lubrication/penile erection, ability to reach orgasm, and satisfaction from orgasm. The scale ranges from 5 to 30, with higher scores indicating more sexual dysfunction. This study assesses the internal consistency, test-retest reliability, and convergent and discriminant validity of the ASEX. The ASEX demonstrated excellent internal consistency (Cronbach’s alpha = .9055) and strong test-retest reliability (for patients, r = .801, p < .01; for controls, r = .892, p < .01). The ASEX items correlated with the Brief Index of Sexual Functioning (BISF) factors and related items but not with depression scores. ANOVAs revealed significant differences in total ASEX scores between patients and controls, as well as between females and males. The sensitivity and specificity of the ASEX at identifying sexual dysfunction were 82% and 90%, respectively, with positive predictive value (PPV) of 88% and negative predictive value (NPV) of 85%. ROC analysis showed an AUC value of .929 ± .029 for the ASEX, significantly higher than the AUC value of .786 ± .050 for the BISF. The ASEX is a reliable and valid tool for measuring sexual dysfunction, offering advantages over more lengthy scales due to its simplicity, ease of scoring, and ability to quickly identify core elements of sexual dysfunction. However, the study had limitations, including a small sample size and the need for further validation in different populations.