The Biological General Repository for Interaction Datasets (BioGRID) is an open-access archive of genetic and protein interactions curated from the primary biomedical literature for major model organisms. As of September 2012, BioGRID contains over 500,000 manually annotated interactions from more than 30 model organisms, with comprehensive coverage of Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Arabidopsis thaliana. BioGRID collaborates with major model organism databases and engages with the text-mining community to enhance curation workflows. The database provides interactive and downloadable data in various formats and supports a range of bioinformatics tools for data analysis, including a post-translational modification viewer, a graphical viewer, a REST service, and a Cytoscape plugin. BioGRID continues to expand its species coverage and thematic curation projects to facilitate interolog analyses and integrate interaction data from multiple model organisms.The Biological General Repository for Interaction Datasets (BioGRID) is an open-access archive of genetic and protein interactions curated from the primary biomedical literature for major model organisms. As of September 2012, BioGRID contains over 500,000 manually annotated interactions from more than 30 model organisms, with comprehensive coverage of Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Arabidopsis thaliana. BioGRID collaborates with major model organism databases and engages with the text-mining community to enhance curation workflows. The database provides interactive and downloadable data in various formats and supports a range of bioinformatics tools for data analysis, including a post-translational modification viewer, a graphical viewer, a REST service, and a Cytoscape plugin. BioGRID continues to expand its species coverage and thematic curation projects to facilitate interolog analyses and integrate interaction data from multiple model organisms.