The Biological General Repository for Interaction Datasets (BioGRID) is an open-access database that curates and archives protein, genetic, and chemical interactions for various model organisms and humans. As of September 2018, BioGRID contains records for 1,598,688 biological interactions from 55,809 publications across 71 species. The database also includes data on over 700,000 post-translational modification sites and chemical interactions, including human drug targets from the DrugBank database. BioGRID has expanded its scope to include genome-wide CRISPR/Cas9-based screens, with the Open Repository for CRISPR Screens (ORCS) containing over 500 such screens. All data in BioGRID is freely available and can be downloaded in standard formats. The database collaborates with various model organism databases and meta-databases to disseminate its content. BioGRID continues to enhance its curation strategies, particularly for large-scale CRISPR screen data and themed projects focused on specific biological processes and diseases. The database also plans to improve its user interface and infrastructure, aiming for a comprehensive renewal with BioGRID 4.0.The Biological General Repository for Interaction Datasets (BioGRID) is an open-access database that curates and archives protein, genetic, and chemical interactions for various model organisms and humans. As of September 2018, BioGRID contains records for 1,598,688 biological interactions from 55,809 publications across 71 species. The database also includes data on over 700,000 post-translational modification sites and chemical interactions, including human drug targets from the DrugBank database. BioGRID has expanded its scope to include genome-wide CRISPR/Cas9-based screens, with the Open Repository for CRISPR Screens (ORCS) containing over 500 such screens. All data in BioGRID is freely available and can be downloaded in standard formats. The database collaborates with various model organism databases and meta-databases to disseminate its content. BioGRID continues to enhance its curation strategies, particularly for large-scale CRISPR screen data and themed projects focused on specific biological processes and diseases. The database also plans to improve its user interface and infrastructure, aiming for a comprehensive renewal with BioGRID 4.0.