The article "The Biopsychosocial Model 25 Years Later: Principles, Practice, and Scientific Inquiry" by Francesc Borrell-Carrió, MD, Anthony L. Suchman MD, and Ronald M. Epstein MD, revisits and updates the biopsychosocial model, a holistic approach to clinical care that integrates biological, psychological, and social dimensions of illness. The authors emphasize the importance of subjective experience in diagnosis and treatment, advocating for a more participatory clinician-patient relationship. They propose seven pillars of biopsychosocial-oriented clinical practice, including self-awareness, trust cultivation, empathic curiosity, bias reduction, emotional education, informed intuition, and effective communication. The article also discusses the challenges of dualism, reductionism, and the observer effect in medical thinking, and explores the implications of complexity science for understanding causality in clinical practice. The authors conclude that the biopsychosocial model is not a paradigm shift but an expanded application of existing knowledge to address the unique needs of each patient, emphasizing the importance of empathy, compassion, and a human-centered approach in healthcare.The article "The Biopsychosocial Model 25 Years Later: Principles, Practice, and Scientific Inquiry" by Francesc Borrell-Carrió, MD, Anthony L. Suchman MD, and Ronald M. Epstein MD, revisits and updates the biopsychosocial model, a holistic approach to clinical care that integrates biological, psychological, and social dimensions of illness. The authors emphasize the importance of subjective experience in diagnosis and treatment, advocating for a more participatory clinician-patient relationship. They propose seven pillars of biopsychosocial-oriented clinical practice, including self-awareness, trust cultivation, empathic curiosity, bias reduction, emotional education, informed intuition, and effective communication. The article also discusses the challenges of dualism, reductionism, and the observer effect in medical thinking, and explores the implications of complexity science for understanding causality in clinical practice. The authors conclude that the biopsychosocial model is not a paradigm shift but an expanded application of existing knowledge to address the unique needs of each patient, emphasizing the importance of empathy, compassion, and a human-centered approach in healthcare.