The CARE guidelines aim to improve the quality and transparency of case reports by providing a standardized reporting framework. Case reports, which describe medical problems experienced by patients, are essential for identifying new diseases, understanding adverse effects, and guiding clinical practice. However, many case reports lack sufficient detail and rigor, making them difficult to use for research or clinical decision-making. To address this, the CARE Group developed a 13-item checklist to guide the reporting of case reports, ensuring completeness and clarity. The development process involved a three-phase consensus approach, including literature review, face-to-face meetings, and feedback sessions. The checklist includes items such as title, abstract, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up, discussion, patient perspective, and informed consent. These items ensure that case reports provide sufficient detail for clinical study design, early detection of treatment effectiveness, and improved healthcare delivery. The CARE guidelines emphasize the importance of patient-reported outcomes and informed consent, which are critical for ethical publication. They also highlight the need for systematic aggregation of case report data to inform clinical research and improve healthcare outcomes. The guidelines are being disseminated through conferences, journals, and an online platform, with plans for translation and further development for specialized fields. While the guidelines offer a structured approach to case reporting, they also acknowledge limitations, such as the challenge of determining causality in case reports and the need for specialty-specific extensions. The CARE guidelines aim to enhance the value of case reports in the era of clinical trials and systematic reviews, promoting individualized care and data-driven insights. By improving the quality and transparency of case reports, the CARE guidelines support better clinical practice, research, and healthcare delivery.The CARE guidelines aim to improve the quality and transparency of case reports by providing a standardized reporting framework. Case reports, which describe medical problems experienced by patients, are essential for identifying new diseases, understanding adverse effects, and guiding clinical practice. However, many case reports lack sufficient detail and rigor, making them difficult to use for research or clinical decision-making. To address this, the CARE Group developed a 13-item checklist to guide the reporting of case reports, ensuring completeness and clarity. The development process involved a three-phase consensus approach, including literature review, face-to-face meetings, and feedback sessions. The checklist includes items such as title, abstract, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up, discussion, patient perspective, and informed consent. These items ensure that case reports provide sufficient detail for clinical study design, early detection of treatment effectiveness, and improved healthcare delivery. The CARE guidelines emphasize the importance of patient-reported outcomes and informed consent, which are critical for ethical publication. They also highlight the need for systematic aggregation of case report data to inform clinical research and improve healthcare outcomes. The guidelines are being disseminated through conferences, journals, and an online platform, with plans for translation and further development for specialized fields. While the guidelines offer a structured approach to case reporting, they also acknowledge limitations, such as the challenge of determining causality in case reports and the need for specialty-specific extensions. The CARE guidelines aim to enhance the value of case reports in the era of clinical trials and systematic reviews, promoting individualized care and data-driven insights. By improving the quality and transparency of case reports, the CARE guidelines support better clinical practice, research, and healthcare delivery.