The CARE (CAsReport) guidelines are a set of systematic reporting standards designed to improve the completeness and transparency of published case reports. The guidelines were developed through a three-phase consensus process involving 27 participants, resulting in a 13-item checklist. The checklist covers essential components such as title, keywords, abstract, introduction, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up and outcomes, discussion, patient perspective, and informed consent. The guidelines aim to enhance the value of case reports by providing a structured framework that can inform clinical study design, early signals of effectiveness and harms, and improve healthcare delivery. The implementation of these guidelines by medical journals is expected to improve the quality and utility of published case reports.The CARE (CAsReport) guidelines are a set of systematic reporting standards designed to improve the completeness and transparency of published case reports. The guidelines were developed through a three-phase consensus process involving 27 participants, resulting in a 13-item checklist. The checklist covers essential components such as title, keywords, abstract, introduction, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up and outcomes, discussion, patient perspective, and informed consent. The guidelines aim to enhance the value of case reports by providing a structured framework that can inform clinical study design, early signals of effectiveness and harms, and improve healthcare delivery. The implementation of these guidelines by medical journals is expected to improve the quality and utility of published case reports.