The CARE Guidelines: Consensus-based Clinical Case Reporting Guideline Development The CARE (CAse REport) guidelines aim to improve the completeness and transparency of published case reports by providing a systematic reporting framework. Developed through a three-phase consensus process involving 27 participants, the guidelines include a 13-item checklist covering key elements such as title, abstract, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up and outcomes, discussion, patient perspective, and informed consent. The guidelines emphasize the importance of structured reporting to enhance the rigor of case reports, inform clinical study design, and improve healthcare delivery. Case reports are essential for identifying adverse and beneficial effects, recognizing new diseases, and guiding individualized treatment. However, many case reports lack sufficient detail and are not rigorously reported, limiting their utility. The CARE guidelines address this by providing standardized reporting recommendations, ensuring that case reports include essential information for clinical practice and research. The guidelines were developed through a consensus process involving literature review, face-to-face meetings, and feedback. They are intended for use by medical journals to improve the quality of case reports. The guidelines also emphasize the importance of patient-reported outcomes and informed consent, and they are supported by empirical evidence showing that reporting guidelines improve the completeness of scientific reports. The CARE guidelines are being disseminated through international conferences, multiple medical journals, and online platforms. They are also being translated into multiple languages and will be available on dedicated websites. The guidelines encourage feedback from authors, journal editors, and the broader medical community to ensure continuous improvement. The CARE guidelines provide a framework for systematic reporting of case reports, enhancing their value in clinical practice and research. They are expected to contribute to the early discovery of effectiveness and harms, and to improve healthcare delivery through data-driven insights. The guidelines are part of a growing effort to standardize and improve the reporting of case reports in medical literature.The CARE Guidelines: Consensus-based Clinical Case Reporting Guideline Development The CARE (CAse REport) guidelines aim to improve the completeness and transparency of published case reports by providing a systematic reporting framework. Developed through a three-phase consensus process involving 27 participants, the guidelines include a 13-item checklist covering key elements such as title, abstract, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up and outcomes, discussion, patient perspective, and informed consent. The guidelines emphasize the importance of structured reporting to enhance the rigor of case reports, inform clinical study design, and improve healthcare delivery. Case reports are essential for identifying adverse and beneficial effects, recognizing new diseases, and guiding individualized treatment. However, many case reports lack sufficient detail and are not rigorously reported, limiting their utility. The CARE guidelines address this by providing standardized reporting recommendations, ensuring that case reports include essential information for clinical practice and research. The guidelines were developed through a consensus process involving literature review, face-to-face meetings, and feedback. They are intended for use by medical journals to improve the quality of case reports. The guidelines also emphasize the importance of patient-reported outcomes and informed consent, and they are supported by empirical evidence showing that reporting guidelines improve the completeness of scientific reports. The CARE guidelines are being disseminated through international conferences, multiple medical journals, and online platforms. They are also being translated into multiple languages and will be available on dedicated websites. The guidelines encourage feedback from authors, journal editors, and the broader medical community to ensure continuous improvement. The CARE guidelines provide a framework for systematic reporting of case reports, enhancing their value in clinical practice and research. They are expected to contribute to the early discovery of effectiveness and harms, and to improve healthcare delivery through data-driven insights. The guidelines are part of a growing effort to standardize and improve the reporting of case reports in medical literature.