The Cancer Genome Atlas (TCGA) is a public-funded project aimed at cataloging and discovering major cancer-causing genomic alterations to create a comprehensive "atlas" of cancer genomic profiles. TCGA has analyzed over 30 human tumor types using large-scale genome sequencing and integrated multi-dimensional analyses, leading to significant advances in understanding tumorigenesis. The project's goals include improving diagnostic methods, treatment standards, and cancer prevention by providing publicly available datasets. TCGA involves multiple centers for sample collection, processing, and analysis, with data shared through secure repositories and analysis tools. The project has identified key genomic alterations in various cancers, such as glioblastoma, breast cancer, ovarian cancer, lung cancer, and others, leading to new therapeutic targets and insights into cancer biology. TCGA has also contributed to the development of new visualization and analysis tools for genomic data, enabling researchers to explore cancer genomics in depth. The project has facilitated the identification of molecular subtypes of cancers, such as endometrial carcinoma and gastric adenocarcinoma, and has provided a comprehensive view of cancer genomics across multiple cancer types. TCGA's data has been instrumental in advancing cancer research, leading to improved diagnostic methods, personalized treatment strategies, and a better understanding of cancer mechanisms. The project continues to expand its scope, with ongoing efforts to integrate data across multiple cancers and improve the resolution of genomic analyses. TCGA's contributions have significantly enhanced our understanding of cancer genomics and have the potential to revolutionize cancer treatment and prevention.The Cancer Genome Atlas (TCGA) is a public-funded project aimed at cataloging and discovering major cancer-causing genomic alterations to create a comprehensive "atlas" of cancer genomic profiles. TCGA has analyzed over 30 human tumor types using large-scale genome sequencing and integrated multi-dimensional analyses, leading to significant advances in understanding tumorigenesis. The project's goals include improving diagnostic methods, treatment standards, and cancer prevention by providing publicly available datasets. TCGA involves multiple centers for sample collection, processing, and analysis, with data shared through secure repositories and analysis tools. The project has identified key genomic alterations in various cancers, such as glioblastoma, breast cancer, ovarian cancer, lung cancer, and others, leading to new therapeutic targets and insights into cancer biology. TCGA has also contributed to the development of new visualization and analysis tools for genomic data, enabling researchers to explore cancer genomics in depth. The project has facilitated the identification of molecular subtypes of cancers, such as endometrial carcinoma and gastric adenocarcinoma, and has provided a comprehensive view of cancer genomics across multiple cancer types. TCGA's data has been instrumental in advancing cancer research, leading to improved diagnostic methods, personalized treatment strategies, and a better understanding of cancer mechanisms. The project continues to expand its scope, with ongoing efforts to integrate data across multiple cancers and improve the resolution of genomic analyses. TCGA's contributions have significantly enhanced our understanding of cancer genomics and have the potential to revolutionize cancer treatment and prevention.