The Carbohydrate-Active Enzymes (CAZy) database is a specialized resource for enzymes involved in the breakdown and synthesis of complex carbohydrates and glycoconjugates. It classifies enzymes into five main families: glycoside hydrolases (GHs), glycosyltransferases (GTs), polysaccharide lyases (PLs), carbohydrate esterases (CEs), and carbohydrate-binding modules (CBMs). These families are based on experimental data and sequence similarity. The database includes over 6,400 proteins with EC numbers and 700 with PDB structures. It provides a framework for understanding enzyme mechanisms and evolutionary relationships. The CAZy database has been available for over 10 years, contributing to glycobiology research and functional annotation of genome projects. It is updated regularly with new sequences and biochemical information. The database includes information from public sources, family classifications, and functional data. It allows exploration of enzymes, families, and organisms. The CAZy database also includes tools for modular assignment and functional analysis. It has been used to analyze genomes and metagenomes, providing insights into carbohydrate metabolism. The database is available online at www.cazy.org. The CAZy database is continuously updated and growing as new data becomes available. It is a fluid database that reflects the latest research and discoveries in carbohydrate-active enzymes. The database is a valuable resource for glycobiologists and researchers in related fields.The Carbohydrate-Active Enzymes (CAZy) database is a specialized resource for enzymes involved in the breakdown and synthesis of complex carbohydrates and glycoconjugates. It classifies enzymes into five main families: glycoside hydrolases (GHs), glycosyltransferases (GTs), polysaccharide lyases (PLs), carbohydrate esterases (CEs), and carbohydrate-binding modules (CBMs). These families are based on experimental data and sequence similarity. The database includes over 6,400 proteins with EC numbers and 700 with PDB structures. It provides a framework for understanding enzyme mechanisms and evolutionary relationships. The CAZy database has been available for over 10 years, contributing to glycobiology research and functional annotation of genome projects. It is updated regularly with new sequences and biochemical information. The database includes information from public sources, family classifications, and functional data. It allows exploration of enzymes, families, and organisms. The CAZy database also includes tools for modular assignment and functional analysis. It has been used to analyze genomes and metagenomes, providing insights into carbohydrate metabolism. The database is available online at www.cazy.org. The CAZy database is continuously updated and growing as new data becomes available. It is a fluid database that reflects the latest research and discoveries in carbohydrate-active enzymes. The database is a valuable resource for glycobiologists and researchers in related fields.