The article "The Chemical Reactivity of Membrane Lipids" by Genevieve Duché and John M Sanderson provides a comprehensive review of the chemical reactivity of membrane lipids, focusing on their bilayer form. The review highlights the unique biophysical and physicochemical properties of lipid bilayers, which are influenced by the water-poor, low dielectric core and the more polar, hydrated interfacial region. The text discusses various chemical reactions that can occur in lipid bilayers, including lytic reactions of glycerol esters (hydrolysis, aminolysis, and transesterification), oxidation reactions of alkenes in unsaturated fatty acids and sterols (autoxidation and oxidation by singlet oxygen), reactivity of headgroups with reactive carbonyl species, and E/Z isomerization of alkenes. The authors also explore the biological and biophysical consequences of these reactions, such as changes in membrane stability, permeability, and the formation of lipid rafts. The review emphasizes the importance of understanding lipid chemistry for applications in drug delivery, food processing, and cosmetics, while also addressing the challenges in studying lipid reactivity due to the complex nature of lipid mixtures and the difficulty in detecting low-abundance products.The article "The Chemical Reactivity of Membrane Lipids" by Genevieve Duché and John M Sanderson provides a comprehensive review of the chemical reactivity of membrane lipids, focusing on their bilayer form. The review highlights the unique biophysical and physicochemical properties of lipid bilayers, which are influenced by the water-poor, low dielectric core and the more polar, hydrated interfacial region. The text discusses various chemical reactions that can occur in lipid bilayers, including lytic reactions of glycerol esters (hydrolysis, aminolysis, and transesterification), oxidation reactions of alkenes in unsaturated fatty acids and sterols (autoxidation and oxidation by singlet oxygen), reactivity of headgroups with reactive carbonyl species, and E/Z isomerization of alkenes. The authors also explore the biological and biophysical consequences of these reactions, such as changes in membrane stability, permeability, and the formation of lipid rafts. The review emphasizes the importance of understanding lipid chemistry for applications in drug delivery, food processing, and cosmetics, while also addressing the challenges in studying lipid reactivity due to the complex nature of lipid mixtures and the difficulty in detecting low-abundance products.