This article provides an overview of the chemistry of curcumin, a pigment derived from turmeric, which has been extensively studied for its biological and chemical properties. The review covers various aspects of curcumin, including extraction methods from turmeric, laboratory synthesis, chemical and photochemical degradation, and its metabolism. It also discusses other chemical reactions such as nucleophilic addition and metal chelation, and recent advances in the preparation of curcumin nanoconjugates with metal and metal oxide nanoparticles. The article highlights the potential of curcumin in developing new therapeutic agents and suggests future research directions in the chemistry of curcumin.This article provides an overview of the chemistry of curcumin, a pigment derived from turmeric, which has been extensively studied for its biological and chemical properties. The review covers various aspects of curcumin, including extraction methods from turmeric, laboratory synthesis, chemical and photochemical degradation, and its metabolism. It also discusses other chemical reactions such as nucleophilic addition and metal chelation, and recent advances in the preparation of curcumin nanoconjugates with metal and metal oxide nanoparticles. The article highlights the potential of curcumin in developing new therapeutic agents and suggests future research directions in the chemistry of curcumin.