The paper "The Cultural Adaptation of Prevention Interventions: Resolving Tensions Between Fidelity and Fit" by Felipe González Castro, Manuel Barrera, Jr., and Charles R. Martinez, Jr., explores the dynamic tension between fidelity of implementation and program adaptation in prevention science. Fidelity refers to the strict adherence to a prescribed manualized intervention, while adaptation involves modifying the program to meet the specific needs of a community. The authors advocate for a community-based participatory research approach that emphasizes community participation to enhance program outcomes. They present key concepts and implementation strategies to address the tension between fidelity and adaptation, emphasizing the need for a planned and systematic approach. An innovative strategy is proposed to develop hybrid prevention programs that balance adaptation and fidelity, ensuring both cultural relevance and scientific effectiveness. The paper highlights the importance of culturally informed programs, particularly for racial/ethnic minority groups, and discusses the challenges and strategies for addressing program-community mismatches.The paper "The Cultural Adaptation of Prevention Interventions: Resolving Tensions Between Fidelity and Fit" by Felipe González Castro, Manuel Barrera, Jr., and Charles R. Martinez, Jr., explores the dynamic tension between fidelity of implementation and program adaptation in prevention science. Fidelity refers to the strict adherence to a prescribed manualized intervention, while adaptation involves modifying the program to meet the specific needs of a community. The authors advocate for a community-based participatory research approach that emphasizes community participation to enhance program outcomes. They present key concepts and implementation strategies to address the tension between fidelity and adaptation, emphasizing the need for a planned and systematic approach. An innovative strategy is proposed to develop hybrid prevention programs that balance adaptation and fidelity, ensuring both cultural relevance and scientific effectiveness. The paper highlights the importance of culturally informed programs, particularly for racial/ethnic minority groups, and discusses the challenges and strategies for addressing program-community mismatches.