The Danish National Prescription Registry (DNPR) is a comprehensive database containing information on all prescription drugs dispensed in Danish community pharmacies since 1994. It is maintained by the Danish Medicines Agency and provides individual-level data on prescriptions, including details about the drug user, prescriber, and pharmacy. The DNPR is a powerful tool for pharmacoepidemiological research due to its high quality data and ability to link with other nationwide individual-level data sources. The data is recorded through automated bar-code-based data entry, ensuring accuracy and completeness. The DNPR includes variables such as the individual's unique personal identification number (CPR-number), prescriber information, drug details, and pharmacy information. It also contains information on the dispensed drug, including the Nordic article number, global Anatomical Therapeutic Chemical (ATC) code, and defined daily dose (DDD). The DNPR does not include information on non-prescribed drugs, drugs dispensed in hospitals for outpatient treatment, or prescriptions not filled. It also lacks information on the prescribed daily dose and indication for prescribing the drug. The DNPR has undergone only minor changes since its initiation, and all Danish pharmacies are still required to register dispensed prescriptions electronically. The DNPR is one of the few individual-level prescription registers that cover an entire nation and has the potential to be one of the world's most powerful pharmacoplasmic biological tools. The research was supported by a grant from the Nordea Foundation for the Center for Healthy Ageing.The Danish National Prescription Registry (DNPR) is a comprehensive database containing information on all prescription drugs dispensed in Danish community pharmacies since 1994. It is maintained by the Danish Medicines Agency and provides individual-level data on prescriptions, including details about the drug user, prescriber, and pharmacy. The DNPR is a powerful tool for pharmacoepidemiological research due to its high quality data and ability to link with other nationwide individual-level data sources. The data is recorded through automated bar-code-based data entry, ensuring accuracy and completeness. The DNPR includes variables such as the individual's unique personal identification number (CPR-number), prescriber information, drug details, and pharmacy information. It also contains information on the dispensed drug, including the Nordic article number, global Anatomical Therapeutic Chemical (ATC) code, and defined daily dose (DDD). The DNPR does not include information on non-prescribed drugs, drugs dispensed in hospitals for outpatient treatment, or prescriptions not filled. It also lacks information on the prescribed daily dose and indication for prescribing the drug. The DNPR has undergone only minor changes since its initiation, and all Danish pharmacies are still required to register dispensed prescriptions electronically. The DNPR is one of the few individual-level prescription registers that cover an entire nation and has the potential to be one of the world's most powerful pharmacoplasmic biological tools. The research was supported by a grant from the Nordea Foundation for the Center for Healthy Ageing.