This section provides supplemental information for the study on the dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells (PGCs). It includes detailed figures and legends, extended experimental procedures, and supplemental references. The figures cover various aspects of methylation dynamics, such as global methylation profiling, promoters with slow demethylating kinetics, resistance to demethylation, and correlation analysis for transcription and DNA methylation. The experimental procedures section outlines methods for DNA/RNA purification, annotations, BS-Seq and RNA-Seq analysis, and functional enrichment analysis. The supplemental references provide additional context and supporting data from previous studies.This section provides supplemental information for the study on the dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells (PGCs). It includes detailed figures and legends, extended experimental procedures, and supplemental references. The figures cover various aspects of methylation dynamics, such as global methylation profiling, promoters with slow demethylating kinetics, resistance to demethylation, and correlation analysis for transcription and DNA methylation. The experimental procedures section outlines methods for DNA/RNA purification, annotations, BS-Seq and RNA-Seq analysis, and functional enrichment analysis. The supplemental references provide additional context and supporting data from previous studies.