The article discusses the growing global burden of Parkinson's disease, which is now the fastest-growing neurological disorder. From 1990 to 2015, the number of people with Parkinson's doubled to over 6 million, and it is projected to double again by 2040, potentially reaching over 12 million. Additional factors, such as increasing longevity, declining smoking rates, and industrialization, could push this number to over 17 million. Parkinson's disease was once rare but is now a "pandemic" due to demographic and industrial changes. The disease is increasing in every major region of the world, and its prevalence is rising due to aging populations, longer life expectancy, and environmental factors. The incidence of Parkinson's disease is also linked to industrial by-products, including pesticides, solvents, and heavy metals. Declining smoking rates may also contribute to higher incidence, as smoking is associated with a reduced risk of Parkinson's. The article highlights the need for increased awareness, activism, and research to address the growing burden of Parkinson's disease. It emphasizes the importance of understanding the environmental, genetic, and biological causes of the disease and developing new treatments and care models. The article also notes that the lifetime risk of Parkinson's disease is now 1 in 15, and the economic and social costs of the disease are substantial. The authors call for a "PACT" to prevent, advocate for, care for, and treat Parkinson's disease, emphasizing the need for new, highly effective therapies. They argue that while the disease is increasing, it is preventable through better understanding and action. The article concludes by highlighting the need for global cooperation and research to address the growing challenge of Parkinson's disease.The article discusses the growing global burden of Parkinson's disease, which is now the fastest-growing neurological disorder. From 1990 to 2015, the number of people with Parkinson's doubled to over 6 million, and it is projected to double again by 2040, potentially reaching over 12 million. Additional factors, such as increasing longevity, declining smoking rates, and industrialization, could push this number to over 17 million. Parkinson's disease was once rare but is now a "pandemic" due to demographic and industrial changes. The disease is increasing in every major region of the world, and its prevalence is rising due to aging populations, longer life expectancy, and environmental factors. The incidence of Parkinson's disease is also linked to industrial by-products, including pesticides, solvents, and heavy metals. Declining smoking rates may also contribute to higher incidence, as smoking is associated with a reduced risk of Parkinson's. The article highlights the need for increased awareness, activism, and research to address the growing burden of Parkinson's disease. It emphasizes the importance of understanding the environmental, genetic, and biological causes of the disease and developing new treatments and care models. The article also notes that the lifetime risk of Parkinson's disease is now 1 in 15, and the economic and social costs of the disease are substantial. The authors call for a "PACT" to prevent, advocate for, care for, and treat Parkinson's disease, emphasizing the need for new, highly effective therapies. They argue that while the disease is increasing, it is preventable through better understanding and action. The article concludes by highlighting the need for global cooperation and research to address the growing challenge of Parkinson's disease.