This study analyzed the epidemiology of revision total knee arthroplasty (TKA) in the United States using data from the Nationwide Inpatient Sample (NIS) database. The study reviewed 60,355 revision TKA procedures performed between October 1, 2005, and December 31, 2006. The most common causes of revision TKA were infection (25.2%) and implant loosening (16.1%), with the most common type of revision TKA being all component revision (35.2%). Revision TKA procedures were most commonly performed in large, urban, non-teaching hospitals in Medicare patients aged 65 to 74. The average length of hospital stay was 5.1 days, and the average total charges were $49,360. These values varied by census region, hospital type, and procedure performed. The study also found that 91% of revision TKA procedures were coded using the newly implemented ICD-9-CM diagnosis and procedure codes. The most common types of revision TKA procedures were all component revision (35.2%), arthrotony/removal of prosthesis (15.2%), and tibial component revision (9.5%). The study highlights the importance of accurate coding for tracking clinical outcomes and improving the accuracy of administrative codes related to TKA failure and revision TKA. The findings suggest that the newly implemented codes are being widely adopted, but there is potential for improvement in their use. The study also emphasizes the need for detailed clinical documentation to ensure the accuracy and clinical relevance of administrative codes related to TKA failure and revision TKA. The results indicate that prosthetic joint infection is currently the most common indication for revision TKA in the United States. The study concludes that further research is needed to determine if these findings persist in larger data sets over longer time periods. The study also highlights the value of large administrative databases in evaluating the epidemiology of revision TKA in a large population.This study analyzed the epidemiology of revision total knee arthroplasty (TKA) in the United States using data from the Nationwide Inpatient Sample (NIS) database. The study reviewed 60,355 revision TKA procedures performed between October 1, 2005, and December 31, 2006. The most common causes of revision TKA were infection (25.2%) and implant loosening (16.1%), with the most common type of revision TKA being all component revision (35.2%). Revision TKA procedures were most commonly performed in large, urban, non-teaching hospitals in Medicare patients aged 65 to 74. The average length of hospital stay was 5.1 days, and the average total charges were $49,360. These values varied by census region, hospital type, and procedure performed. The study also found that 91% of revision TKA procedures were coded using the newly implemented ICD-9-CM diagnosis and procedure codes. The most common types of revision TKA procedures were all component revision (35.2%), arthrotony/removal of prosthesis (15.2%), and tibial component revision (9.5%). The study highlights the importance of accurate coding for tracking clinical outcomes and improving the accuracy of administrative codes related to TKA failure and revision TKA. The findings suggest that the newly implemented codes are being widely adopted, but there is potential for improvement in their use. The study also emphasizes the need for detailed clinical documentation to ensure the accuracy and clinical relevance of administrative codes related to TKA failure and revision TKA. The results indicate that prosthetic joint infection is currently the most common indication for revision TKA in the United States. The study concludes that further research is needed to determine if these findings persist in larger data sets over longer time periods. The study also highlights the value of large administrative databases in evaluating the epidemiology of revision TKA in a large population.