The 2021 One Health Zoonoses Report by the European Centre for Disease Prevention and Control (ECDC) and the European Food Safety Authority (EFSA) provides an overview of zoonotic diseases, which are infectious diseases transmitted between animals and humans. The report highlights the occurrence of zoonotic microorganisms in various sources, including food, feed, animals, and humans, and analyzes trends in zoonotic agent prevalence. - **Data Sources**: ECDC and EFSA collect data from EU Member States and other European countries on zoonotic diseases, covering food and feed sources, food-producing animals, companion and wild animals, and human illnesses. - **Scope**: The report includes detailed data on main zoonoses reported by Member States, with mandatory reporting for well-known agents like *Salmonella*, *Campylobacter*, and *Listeria monocytogenes*, and optional reporting for less common agents. - **Most Commonly Reported Zoonoses**: In 2021, campylobacteriosis and salmonellosis were the most common gastrointestinal diseases, with an increase of around 7,000 cases each compared to 2020. - **Impact of COVID-19**: The withdrawal of the UK from the EU and partial or total lockdowns influenced data collection and analysis, leading to a need for careful interpretation of reported case increases. - **Salmonella Control**: National *Salmonella* control programs have been effective in reducing prevalence in poultry populations. In 2021, 16 Member States and Northern Ireland achieved targets for reducing *Salmonella* prevalence. - **Yersiniosis, STEC, and Listeriosis**: Yersiniosis, caused by *Y. enterocolitica*, was the third most common zoonosis. Shiga toxin-producing *Escherichia coli* (STEC) and listeriosis were also significant, with *L. monocytogenes* causing severe and fatal illnesses. - **Foodborne Outbreaks**: In 2021, 27 Member States and Northern Ireland reported 4,005 foodborne outbreaks and 32,543 human cases, a significant increase from 2020. *Salmonella*, particularly *S. Enteritidis*, remained the most frequent cause, with outbreaks linked to eggs, mixed foods, and vegetables increasing. The report emphasizes the importance of a "One Health" approach in addressing zoonotic diseases, involving collaboration among human, animal, and environmental health sectors. It provides valuable insights for veterinary and food safety authorities and policymakers to reduce the burden of zoonotic pathogens.The 2021 One Health Zoonoses Report by the European Centre for Disease Prevention and Control (ECDC) and the European Food Safety Authority (EFSA) provides an overview of zoonotic diseases, which are infectious diseases transmitted between animals and humans. The report highlights the occurrence of zoonotic microorganisms in various sources, including food, feed, animals, and humans, and analyzes trends in zoonotic agent prevalence. - **Data Sources**: ECDC and EFSA collect data from EU Member States and other European countries on zoonotic diseases, covering food and feed sources, food-producing animals, companion and wild animals, and human illnesses. - **Scope**: The report includes detailed data on main zoonoses reported by Member States, with mandatory reporting for well-known agents like *Salmonella*, *Campylobacter*, and *Listeria monocytogenes*, and optional reporting for less common agents. - **Most Commonly Reported Zoonoses**: In 2021, campylobacteriosis and salmonellosis were the most common gastrointestinal diseases, with an increase of around 7,000 cases each compared to 2020. - **Impact of COVID-19**: The withdrawal of the UK from the EU and partial or total lockdowns influenced data collection and analysis, leading to a need for careful interpretation of reported case increases. - **Salmonella Control**: National *Salmonella* control programs have been effective in reducing prevalence in poultry populations. In 2021, 16 Member States and Northern Ireland achieved targets for reducing *Salmonella* prevalence. - **Yersiniosis, STEC, and Listeriosis**: Yersiniosis, caused by *Y. enterocolitica*, was the third most common zoonosis. Shiga toxin-producing *Escherichia coli* (STEC) and listeriosis were also significant, with *L. monocytogenes* causing severe and fatal illnesses. - **Foodborne Outbreaks**: In 2021, 27 Member States and Northern Ireland reported 4,005 foodborne outbreaks and 32,543 human cases, a significant increase from 2020. *Salmonella*, particularly *S. Enteritidis*, remained the most frequent cause, with outbreaks linked to eggs, mixed foods, and vegetables increasing. The report emphasizes the importance of a "One Health" approach in addressing zoonotic diseases, involving collaboration among human, animal, and environmental health sectors. It provides valuable insights for veterinary and food safety authorities and policymakers to reduce the burden of zoonotic pathogens.