The Gene Expression Omnibus (GEO) database is a public repository that archives and freely distributes high-throughput gene expression and other functional genomics data. Established in 2000 by the National Center for Biotechnology Information (NCBI), GEO has evolved to accommodate various data types, including genome methylation, chromatin structure, and genome-protein interactions. It supports community-derived standards for data submission, ensuring the availability of raw, processed data, and metadata. GEO provides access to tens of thousands of studies, along with web-based tools for data retrieval, visualization, and analysis. The database is a global resource, with submissions from 72 countries, and offers free access to data and tools. GEO supports standards like MIAME and MINSEQ for data standardization, and contains over 54,640 public studies from 2889 organisms. It offers various search methods, including keyword searches, structured queries, and filters, as well as programmatic access via E-utils. GEO also provides tools for data analysis, such as GEO2R for differential expression analysis, and visualization tools for gene expression profiles. Additionally, GEO supports genome-wide data visualization through the Genome Data Viewer, allowing users to explore data as genome tracks. The database continues to evolve to meet new data types and improve access to data. GEO is widely used in research, with thousands of publications reusing and reanalyzing its data to develop new hypotheses and applications. The database is a key resource for the scientific community, facilitating data sharing, analysis, and discovery.The Gene Expression Omnibus (GEO) database is a public repository that archives and freely distributes high-throughput gene expression and other functional genomics data. Established in 2000 by the National Center for Biotechnology Information (NCBI), GEO has evolved to accommodate various data types, including genome methylation, chromatin structure, and genome-protein interactions. It supports community-derived standards for data submission, ensuring the availability of raw, processed data, and metadata. GEO provides access to tens of thousands of studies, along with web-based tools for data retrieval, visualization, and analysis. The database is a global resource, with submissions from 72 countries, and offers free access to data and tools. GEO supports standards like MIAME and MINSEQ for data standardization, and contains over 54,640 public studies from 2889 organisms. It offers various search methods, including keyword searches, structured queries, and filters, as well as programmatic access via E-utils. GEO also provides tools for data analysis, such as GEO2R for differential expression analysis, and visualization tools for gene expression profiles. Additionally, GEO supports genome-wide data visualization through the Genome Data Viewer, allowing users to explore data as genome tracks. The database continues to evolve to meet new data types and improve access to data. GEO is widely used in research, with thousands of publications reusing and reanalyzing its data to develop new hypotheses and applications. The database is a key resource for the scientific community, facilitating data sharing, analysis, and discovery.