The article provides a comprehensive overview of the genus *Aeromonas*, covering its taxonomy, pathogenicity, and infection. It begins with an introduction to the history and evolution of the genus, highlighting the significant advancements in understanding and research over the past century. The article then delves into the nomenclature and taxonomy of *Aeromonas*, discussing the challenges and controversies in species classification, including the use of hybridization groups (HGs) and the need for standardized methods for species description. The text explores the current status of *Aeromonas* species, emphasizing the expansion of the genus and the increasing number of newly described species. It also addresses the ecological distribution of *Aeromonas*, particularly in aquatic environments, and its role in fish diseases. The article further discusses the epidemiology of *Aeromonas* infections, including clinical infections and disease syndromes such as gastroenteritis, septicemia, and skin and soft tissue infections. The pathogenicity of *Aeromonas* is examined, detailing its ability to cause infections in both immunocompetent and immunocompromised individuals. The laboratory identification of *Aeromonas* is covered, including isolation, identification, and the use of commercial systems and molecular techniques. The antimicrobial susceptibility patterns and resistance mechanisms of *Aeromonas* are also discussed, with a focus on β-lactamases and quinolones. Finally, the article concludes by emphasizing the importance of further research and standardized practices in the study of *Aeromonas* to better understand its role in infectious diseases and environmental ecosystems.The article provides a comprehensive overview of the genus *Aeromonas*, covering its taxonomy, pathogenicity, and infection. It begins with an introduction to the history and evolution of the genus, highlighting the significant advancements in understanding and research over the past century. The article then delves into the nomenclature and taxonomy of *Aeromonas*, discussing the challenges and controversies in species classification, including the use of hybridization groups (HGs) and the need for standardized methods for species description. The text explores the current status of *Aeromonas* species, emphasizing the expansion of the genus and the increasing number of newly described species. It also addresses the ecological distribution of *Aeromonas*, particularly in aquatic environments, and its role in fish diseases. The article further discusses the epidemiology of *Aeromonas* infections, including clinical infections and disease syndromes such as gastroenteritis, septicemia, and skin and soft tissue infections. The pathogenicity of *Aeromonas* is examined, detailing its ability to cause infections in both immunocompetent and immunocompromised individuals. The laboratory identification of *Aeromonas* is covered, including isolation, identification, and the use of commercial systems and molecular techniques. The antimicrobial susceptibility patterns and resistance mechanisms of *Aeromonas* are also discussed, with a focus on β-lactamases and quinolones. Finally, the article concludes by emphasizing the importance of further research and standardized practices in the study of *Aeromonas* to better understand its role in infectious diseases and environmental ecosystems.