The CD-Bonn potential is a high-precision, charge-dependent nucleon-nucleon (NN) potential that fits the world proton-proton data below 350 MeV with a χ² per datum of 1.01 for 2932 data points and the corresponding neutron-proton data with χ²/datum = 1.02 for 3058 data points. This accuracy surpasses that of any phase-shift analysis or other NN potential. The charge dependence of the CD-Bonn potential is based on the Bonn Full Model's predictions for charge-symmetry and charge-independence breaking in all partial waves with J ≤ 4. The potential is represented using nonlocal covariant Feynman amplitudes for one-boson exchange, leading to distinct off-shell behavior compared to local potentials and resulting in larger binding energies in nuclear systems. The CD-Bonn potential is constructed using the Bonn Full Model, which includes all mesons with masses below the nucleon mass (π, η, ρ(770), ω(782)) and two scalar-isoscalar σ bosons. The potential is derived from Lagrangians describing the coupling of mesons to nucleons. The one-boson-exchange potential is defined by summing the Feynman amplitudes of the included mesons, with form factors and square-root factors to ensure relativistic consistency. The potential accurately reproduces charge-symmetry and charge-independence breaking effects, including the Nolen-Schiffer anomaly. The CD-Bonn potential is used to calculate NN scattering and deuteron properties, showing good agreement with experimental data. The deuteron binding energy is predicted with high accuracy, and the deuteron D-state probability is found to be 4.85%, lower than local potentials but consistent with nonlocal effects. The CD-Bonn potential is more accurate than other NN potentials in fitting experimental data, particularly for pp spin correlation parameters. It includes charge dependence from both OPE and TBE diagrams, providing a comprehensive description of NN interactions. The potential's nonlocality leads to larger binding energies in nuclear systems and improves predictions for nuclear matter and finite nuclei. The CD-Bonn potential represents a promising starting point for exact few-body calculations and microscopic nuclear many-body theory.The CD-Bonn potential is a high-precision, charge-dependent nucleon-nucleon (NN) potential that fits the world proton-proton data below 350 MeV with a χ² per datum of 1.01 for 2932 data points and the corresponding neutron-proton data with χ²/datum = 1.02 for 3058 data points. This accuracy surpasses that of any phase-shift analysis or other NN potential. The charge dependence of the CD-Bonn potential is based on the Bonn Full Model's predictions for charge-symmetry and charge-independence breaking in all partial waves with J ≤ 4. The potential is represented using nonlocal covariant Feynman amplitudes for one-boson exchange, leading to distinct off-shell behavior compared to local potentials and resulting in larger binding energies in nuclear systems. The CD-Bonn potential is constructed using the Bonn Full Model, which includes all mesons with masses below the nucleon mass (π, η, ρ(770), ω(782)) and two scalar-isoscalar σ bosons. The potential is derived from Lagrangians describing the coupling of mesons to nucleons. The one-boson-exchange potential is defined by summing the Feynman amplitudes of the included mesons, with form factors and square-root factors to ensure relativistic consistency. The potential accurately reproduces charge-symmetry and charge-independence breaking effects, including the Nolen-Schiffer anomaly. The CD-Bonn potential is used to calculate NN scattering and deuteron properties, showing good agreement with experimental data. The deuteron binding energy is predicted with high accuracy, and the deuteron D-state probability is found to be 4.85%, lower than local potentials but consistent with nonlocal effects. The CD-Bonn potential is more accurate than other NN potentials in fitting experimental data, particularly for pp spin correlation parameters. It includes charge dependence from both OPE and TBE diagrams, providing a comprehensive description of NN interactions. The potential's nonlocality leads to larger binding energies in nuclear systems and improves predictions for nuclear matter and finite nuclei. The CD-Bonn potential represents a promising starting point for exact few-body calculations and microscopic nuclear many-body theory.