The IARC TP53 Database provides a comprehensive collection of TP53 mutations, including somatic, germline, and polymorphisms, from published literature since 1989. It is the largest dataset of variations in any human gene and is available online at www.iarc.fr/P53/. The database has been updated and restructured to be patient-centered, with detailed annotations on patient characteristics, and now includes a new online tool for retrieving and analyzing somatic mutation data. The database also includes germline mutations associated with Li-Fraumeni syndrome and common polymorphisms. The database is structured into three independent data types: somatic mutations, germline mutations, and polymorphisms. The database includes only published mutations identified by sequencing, with detailed descriptions in the original publication. The database is available for online search and download, with a user guide and slide show on TP53 mutations. The database has limitations, including potential biases and duplication of entries, and users are advised to refer to original papers for accurate interpretations. The database is maintained by the International Agency for Research on Cancer and is supported by a specific budget. It is a free resource for the scientific community and welcomes contributions from authors to improve the database. The database is also compared with other TP53 mutation databases, which are not regularly updated and may not provide accurate information. The IARC TP53 database is an important resource for researchers studying TP53 mutations in human cancers.The IARC TP53 Database provides a comprehensive collection of TP53 mutations, including somatic, germline, and polymorphisms, from published literature since 1989. It is the largest dataset of variations in any human gene and is available online at www.iarc.fr/P53/. The database has been updated and restructured to be patient-centered, with detailed annotations on patient characteristics, and now includes a new online tool for retrieving and analyzing somatic mutation data. The database also includes germline mutations associated with Li-Fraumeni syndrome and common polymorphisms. The database is structured into three independent data types: somatic mutations, germline mutations, and polymorphisms. The database includes only published mutations identified by sequencing, with detailed descriptions in the original publication. The database is available for online search and download, with a user guide and slide show on TP53 mutations. The database has limitations, including potential biases and duplication of entries, and users are advised to refer to original papers for accurate interpretations. The database is maintained by the International Agency for Research on Cancer and is supported by a specific budget. It is a free resource for the scientific community and welcomes contributions from authors to improve the database. The database is also compared with other TP53 mutation databases, which are not regularly updated and may not provide accurate information. The IARC TP53 database is an important resource for researchers studying TP53 mutations in human cancers.