The IPD-IMGT/HLA Database, first released in 1998, has evolved into a comprehensive resource for human Major Histocompatibility Complex (MHC) sequences. Now containing over 35,000 alleles, it provides a stable and user-friendly platform for the HLA community. The database has grown significantly due to the adoption of Next Generation Sequencing (NGS) technology, leading to an increase in the number of alleles and sequence lengths. To meet the growing demands, the IPD team developed a suite of tools and an Application Programming Interface (API) for enhanced user experience and programmatic access. The IPD-API allows scalable and flexible access to the database, supporting future developments in the HLA field. The IPD-IMGT/HLA Database is a global sequence repository with submissions from 47 countries and users from 191 countries. It is the official repository for the WHO Nomenclature Committee for HLA factors, ensuring the accurate naming and curation of HLA sequences. The database has processed over 57,000 submissions, with the majority coming from HLA typing laboratories and commercial partners. The database now includes over 35,000 alleles, with the number of genes and sequences continuing to grow. The database also provides tools for HLA sequence analysis, including alignment, search, and matching tools, as well as APIs for programmatic access. The IPD-IMGT/HLA Database has been updated every three months since its first release, with the latest release in July 2022 containing 35,077 alleles. The database has seen a significant increase in the number of nucleotides, driven by the use of NGS technology. The primary NGS technologies used are Illumina (short read) and PacBio (long read), with PacBio submissions increasing significantly since 2018. The database now includes full-length sequences, improving the quality of data and reducing bioinformatics challenges. The IPD-IMGT/HLA Database provides a range of tools for HLA sequence analysis, including alignment, search, and matching tools. These tools are accessible via the IPD-IMGT/HLA website and through the IPD-API, which allows programmatic access. The database also provides matching APIs for HLA-DPB1-TCE, HLA-B Leader, and KIR Ligand, which are used to improve donor selection in hematopoietic cell transplantation. The database has been redesigned to improve user experience and performance, with a new website offering a more intuitive interface and improved functionality. The IPD-IMGT/HLA Database continues to develop new tools and features to support the HLA community, including the IPD-API and matching APIs. These developments ensure the database remains a central resource for researchers and clinicians in the HLA field. The database is funded by various organizations and isThe IPD-IMGT/HLA Database, first released in 1998, has evolved into a comprehensive resource for human Major Histocompatibility Complex (MHC) sequences. Now containing over 35,000 alleles, it provides a stable and user-friendly platform for the HLA community. The database has grown significantly due to the adoption of Next Generation Sequencing (NGS) technology, leading to an increase in the number of alleles and sequence lengths. To meet the growing demands, the IPD team developed a suite of tools and an Application Programming Interface (API) for enhanced user experience and programmatic access. The IPD-API allows scalable and flexible access to the database, supporting future developments in the HLA field. The IPD-IMGT/HLA Database is a global sequence repository with submissions from 47 countries and users from 191 countries. It is the official repository for the WHO Nomenclature Committee for HLA factors, ensuring the accurate naming and curation of HLA sequences. The database has processed over 57,000 submissions, with the majority coming from HLA typing laboratories and commercial partners. The database now includes over 35,000 alleles, with the number of genes and sequences continuing to grow. The database also provides tools for HLA sequence analysis, including alignment, search, and matching tools, as well as APIs for programmatic access. The IPD-IMGT/HLA Database has been updated every three months since its first release, with the latest release in July 2022 containing 35,077 alleles. The database has seen a significant increase in the number of nucleotides, driven by the use of NGS technology. The primary NGS technologies used are Illumina (short read) and PacBio (long read), with PacBio submissions increasing significantly since 2018. The database now includes full-length sequences, improving the quality of data and reducing bioinformatics challenges. The IPD-IMGT/HLA Database provides a range of tools for HLA sequence analysis, including alignment, search, and matching tools. These tools are accessible via the IPD-IMGT/HLA website and through the IPD-API, which allows programmatic access. The database also provides matching APIs for HLA-DPB1-TCE, HLA-B Leader, and KIR Ligand, which are used to improve donor selection in hematopoietic cell transplantation. The database has been redesigned to improve user experience and performance, with a new website offering a more intuitive interface and improved functionality. The IPD-IMGT/HLA Database continues to develop new tools and features to support the HLA community, including the IPD-API and matching APIs. These developments ensure the database remains a central resource for researchers and clinicians in the HLA field. The database is funded by various organizations and is