The IPD-IMGT/HLA Database, first released 24 years ago, is a comprehensive repository of highly curated HLA sequences, containing over 35,000 alleles of the human Major Histocompatibility Complex (MHC). The database, maintained by the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI), provides a stable and user-friendly platform for accessing and analyzing HLA data. With the advent of Next Generation Sequencing (NGS) technology, the database has seen a significant increase in the number of alleles and sequence lengths submitted. To accommodate this growth, the IPD team has developed a suite of tools, including the IPD-API, which offers scalable and flexible access to the database. These tools enhance the user experience for traditional web-based users while providing programmatic access for bioinformatics researchers. The IPD-IMGT/HLA Database is a central resource for the HLA community, supporting clinical and research applications, particularly in hematopoietic cell transplantation. The database's evolution and future developments aim to address the increasing complexity and volume of HLA data, ensuring its continued relevance and utility in the field.The IPD-IMGT/HLA Database, first released 24 years ago, is a comprehensive repository of highly curated HLA sequences, containing over 35,000 alleles of the human Major Histocompatibility Complex (MHC). The database, maintained by the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI), provides a stable and user-friendly platform for accessing and analyzing HLA data. With the advent of Next Generation Sequencing (NGS) technology, the database has seen a significant increase in the number of alleles and sequence lengths submitted. To accommodate this growth, the IPD team has developed a suite of tools, including the IPD-API, which offers scalable and flexible access to the database. These tools enhance the user experience for traditional web-based users while providing programmatic access for bioinformatics researchers. The IPD-IMGT/HLA Database is a central resource for the HLA community, supporting clinical and research applications, particularly in hematopoietic cell transplantation. The database's evolution and future developments aim to address the increasing complexity and volume of HLA data, ensuring its continued relevance and utility in the field.