The Immuno Polymorphism Database (IPD) is a centralized resource for studying polymorphic genes in the immune system, including the Major Histocompatibility Complex (MHC). The IPD project involves collaboration with specialist groups and nomenclature committees to curate and publish locus-specific databases. The primary database, IMGT/HLA, provides a locus-specific database for allelic sequences of the HLA system, which is crucial for transplantation and immunogenetics research. The database has been updated regularly to include all publicly available sequences officially named by the WHO Nomenclature Committee. The introduction of Next Generation Sequencing (NGS) techniques has increased the demand for high-quality, comprehensive databases like IMGT/HLA, which are essential for accurate and reliable analysis of HLA sequences. The IPD project continues to develop new tools and refine existing ones to meet the challenges posed by the increasing volume of data and the need for more accurate and comprehensive analysis. The IPD model has also been applied to other highly polymorphic gene systems, such as the KIR genes, and has been adopted by other groups working on MHC sequence variation.The Immuno Polymorphism Database (IPD) is a centralized resource for studying polymorphic genes in the immune system, including the Major Histocompatibility Complex (MHC). The IPD project involves collaboration with specialist groups and nomenclature committees to curate and publish locus-specific databases. The primary database, IMGT/HLA, provides a locus-specific database for allelic sequences of the HLA system, which is crucial for transplantation and immunogenetics research. The database has been updated regularly to include all publicly available sequences officially named by the WHO Nomenclature Committee. The introduction of Next Generation Sequencing (NGS) techniques has increased the demand for high-quality, comprehensive databases like IMGT/HLA, which are essential for accurate and reliable analysis of HLA sequences. The IPD project continues to develop new tools and refine existing ones to meet the challenges posed by the increasing volume of data and the need for more accurate and comprehensive analysis. The IPD model has also been applied to other highly polymorphic gene systems, such as the KIR genes, and has been adopted by other groups working on MHC sequence variation.