The article discusses the growing significance of the intestinal microbiota in diagnosing and treating pancreatic diseases, particularly cancer, pancreatitis, and type 1 diabetes (T1D). Fecal Microbiota Transplantation (FMT) is highlighted as a promising therapeutic approach, involving the transfer of gut microbiota from healthy donors to patients with pancreatic ailments. This procedure aims to restore intestinal balance and alleviate symptoms. Recent research underscores the therapeutic benefits of targeting the gut microbiota for personalized interventions in pancreatic disorders. However, a deeper understanding of the complex interplay between gut microbiota and pancreatic physiology is needed. The article reviews recent studies on how gut microbiota can be utilized in diagnosing pancreatic pathologies and how FMT can impact treatments for various pancreatic disorders. It also explores the role of the gut-pancreatic axis and the potential of FMT in treating pancreatic cancer, acute and chronic pancreatitis, and T1D. The article concludes by emphasizing the need for further research to validate FMT's safety and efficacy in these conditions and to develop tailored therapeutic strategies.The article discusses the growing significance of the intestinal microbiota in diagnosing and treating pancreatic diseases, particularly cancer, pancreatitis, and type 1 diabetes (T1D). Fecal Microbiota Transplantation (FMT) is highlighted as a promising therapeutic approach, involving the transfer of gut microbiota from healthy donors to patients with pancreatic ailments. This procedure aims to restore intestinal balance and alleviate symptoms. Recent research underscores the therapeutic benefits of targeting the gut microbiota for personalized interventions in pancreatic disorders. However, a deeper understanding of the complex interplay between gut microbiota and pancreatic physiology is needed. The article reviews recent studies on how gut microbiota can be utilized in diagnosing pancreatic pathologies and how FMT can impact treatments for various pancreatic disorders. It also explores the role of the gut-pancreatic axis and the potential of FMT in treating pancreatic cancer, acute and chronic pancreatitis, and T1D. The article concludes by emphasizing the need for further research to validate FMT's safety and efficacy in these conditions and to develop tailored therapeutic strategies.