In late 2022, Germany reported an unusual increase in severe, invasive bacterial infections, particularly *Streptococcus pyogenes* and *Haemophilus influenzae*, coinciding with a high incidence of viral respiratory infections. The study analyzed routine data from a laboratory-based surveillance system covering approximately one-third of the German population. In the first quarter of 2023, the number of *S. pyogenes* isolates increased by 142%, and *H. influenzae* isolates by 90%, compared to pre-pandemic seasonal peaks. Adults over 55 and children under 5 were most affected. The rise in infections may be attributed to increased circulation of respiratory pathogens and elevated susceptibility in the population after relaxation of COVID-19 prevention measures. Coinfections with respiratory viruses may have also contributed. The authors recommend continuous surveillance, preventive measures, and vaccination to reduce the risk of infection and severe illness.In late 2022, Germany reported an unusual increase in severe, invasive bacterial infections, particularly *Streptococcus pyogenes* and *Haemophilus influenzae*, coinciding with a high incidence of viral respiratory infections. The study analyzed routine data from a laboratory-based surveillance system covering approximately one-third of the German population. In the first quarter of 2023, the number of *S. pyogenes* isolates increased by 142%, and *H. influenzae* isolates by 90%, compared to pre-pandemic seasonal peaks. Adults over 55 and children under 5 were most affected. The rise in infections may be attributed to increased circulation of respiratory pathogens and elevated susceptibility in the population after relaxation of COVID-19 prevention measures. Coinfections with respiratory viruses may have also contributed. The authors recommend continuous surveillance, preventive measures, and vaccination to reduce the risk of infection and severe illness.