The article "Plasticity of Cell Migration: A Multiscale Tuning Model" by Peter Friedl and Katarina Wolf discusses the complex process of cell migration, which is crucial for tissue formation, maintenance, and regeneration, as well as pathological conditions like cancer invasion. The authors describe how various parameters, including the dimension, density, stiffness, and orientation of the extracellular matrix (ECM), interact with cell-specific factors such as cell-cell and cell-matrix adhesion, cytoskeletal polarity and stiffness, and pericellular proteolysis, to control the mode and efficiency of cell migration. They propose a multi-parameter tuning model that integrates these factors to explain how cells adapt their migration strategies in different physiological and pathological contexts. The model highlights the interdependence of these parameters and their impact on cell movement, emphasizing the plasticity of migration modes in response to environmental and cellular changes.The article "Plasticity of Cell Migration: A Multiscale Tuning Model" by Peter Friedl and Katarina Wolf discusses the complex process of cell migration, which is crucial for tissue formation, maintenance, and regeneration, as well as pathological conditions like cancer invasion. The authors describe how various parameters, including the dimension, density, stiffness, and orientation of the extracellular matrix (ECM), interact with cell-specific factors such as cell-cell and cell-matrix adhesion, cytoskeletal polarity and stiffness, and pericellular proteolysis, to control the mode and efficiency of cell migration. They propose a multi-parameter tuning model that integrates these factors to explain how cells adapt their migration strategies in different physiological and pathological contexts. The model highlights the interdependence of these parameters and their impact on cell movement, emphasizing the plasticity of migration modes in response to environmental and cellular changes.