This study investigates the carcinogenic potential of plastic additives, which are chemical compounds intentionally or unintentionally added to plastics to enhance functionality or remain as residual components. Despite the widespread exposure to plastics, there is limited knowledge about their health consequences. The authors compiled a list of 2,712 known plastic additives through a comprehensive literature search and performed an integrated toxicogenomic analysis focusing on cancer classifications and carcinogenic expression pathways. Key findings include: 1. **Carcinogenicity of Additives**: Over 150 plastic additives have known carcinogenicity, but the majority (∼90%) lack data on carcinogenic endpoints. 2. **Usage Patterns**: Specific polymers, functions, and products contain carcinogenic additives. 3. **Biological Pathways**: Both carcinogenic and unclassified additives impact similar biological pathways, including DNA damage, apoptosis, immune response, viral diseases, and cancer. 4. **Urgent Need for Assessment**: The study underscores the need for systematic and comprehensive carcinogenicity assessments of plastic additives and regulatory responses to mitigate potential health risks. The study highlights the urgent need for more research and regulatory action to address the potential health risks associated with plastic additives.This study investigates the carcinogenic potential of plastic additives, which are chemical compounds intentionally or unintentionally added to plastics to enhance functionality or remain as residual components. Despite the widespread exposure to plastics, there is limited knowledge about their health consequences. The authors compiled a list of 2,712 known plastic additives through a comprehensive literature search and performed an integrated toxicogenomic analysis focusing on cancer classifications and carcinogenic expression pathways. Key findings include: 1. **Carcinogenicity of Additives**: Over 150 plastic additives have known carcinogenicity, but the majority (∼90%) lack data on carcinogenic endpoints. 2. **Usage Patterns**: Specific polymers, functions, and products contain carcinogenic additives. 3. **Biological Pathways**: Both carcinogenic and unclassified additives impact similar biological pathways, including DNA damage, apoptosis, immune response, viral diseases, and cancer. 4. **Urgent Need for Assessment**: The study underscores the need for systematic and comprehensive carcinogenicity assessments of plastic additives and regulatory responses to mitigate potential health risks. The study highlights the urgent need for more research and regulatory action to address the potential health risks associated with plastic additives.