Date:2015
Author:Timothy L. Bailey, James Johnson, Charles E. Grant, William S. Noble
Pages:11
Summary:The MEME Suite is a comprehensive set of web-based tools for studying sequence motifs in proteins, DNA, and RNA. These motifs are crucial for understanding molecular interactions and gene regulation. The suite includes 13 tools for motif discovery, enrichment analysis, scanning, and comparison, with six new tools added since its last publication. The core tool, MEME, is a general-purpose motif discovery algorithm, while other tools like DREME, CentriMo, AME, SpaMo, and MCAST offer specialized functionalities. The suite supports various sequence and motif databases, and provides user-friendly interfaces for inputting sequences and motifs. It also offers extensive documentation and support. Case studies demonstrate the suite's utility in identifying host-targeting signals in malaria parasites, protein interaction motifs, liver-specific genes, and regulatory elements from ChIP-seq data. The MEME Suite is freely available for academic use and can be downloaded for local installation.