The study investigates the association between the use of appetite suppressant drugs and the risk of primary pulmonary hypertension (PPH). The research was conducted in France, Belgium, the United Kingdom, and the Netherlands, involving 95 patients with PPH and 355 matched controls. The results show that the use of anorexic drugs, particularly derivatives of fenfluramine, is significantly associated with an increased risk of PPH. The odds ratio for PPH increased with the duration of anorexic drug use, reaching 23.1 for exposure lasting more than three months. The study also confirmed other known risk factors for PPH, such as a family history of PPH, HIV infection, cirrhosis, and use of cocaine or intravenous drugs. The findings suggest that active surveillance for PPH should be considered, especially given the expected increase in anorexic drug use. The study highlights the need for further research to understand the mechanisms behind the association between anorexic drugs and PPH.The study investigates the association between the use of appetite suppressant drugs and the risk of primary pulmonary hypertension (PPH). The research was conducted in France, Belgium, the United Kingdom, and the Netherlands, involving 95 patients with PPH and 355 matched controls. The results show that the use of anorexic drugs, particularly derivatives of fenfluramine, is significantly associated with an increased risk of PPH. The odds ratio for PPH increased with the duration of anorexic drug use, reaching 23.1 for exposure lasting more than three months. The study also confirmed other known risk factors for PPH, such as a family history of PPH, HIV infection, cirrhosis, and use of cocaine or intravenous drugs. The findings suggest that active surveillance for PPH should be considered, especially given the expected increase in anorexic drug use. The study highlights the need for further research to understand the mechanisms behind the association between anorexic drugs and PPH.