The One Health Concept emphasizes the interconnectedness of human, animal, and environmental health. It recognizes that human health is closely linked to the health of other animals and their environments. The concept has gained traction in response to global challenges such as the COVID-19 pandemic and climate change, prompting international cooperation to address health and welfare issues. The United Nations Sustainable Development Goals include targets related to health, clean water, climate action, and ecosystem sustainability. The One Health Quadripartite, comprising WHO, WOAH, FAO, and UNEP, focuses on six areas: laboratory services, zoonotic disease control, neglected tropical diseases, antimicrobial resistance, food safety, and environmental health. Biomedical and clinical scientists play a key role in applying the One Health approach to healthcare in the 21st century. Laboratory services are crucial for diagnosing infectious diseases, as symptoms can be non-specific. The One Health approach encourages collaboration between medical and veterinary scientists to develop testing protocols. For example, Leishmania parasites affect both humans and animals, and PCR is a valuable diagnostic tool. Laboratory services also support disease surveillance, with many countries collecting data on human pathogens. Similar systems exist for animal diseases, with regional and international monitoring systems in place. Zoonotic diseases require a One Health approach to understand transmission dynamics and control. For example, rabies control in Europe led to an increase in fox populations, which are hosts for Echinococcus multilocularis, a parasite that can infect humans. The One Health approach is essential for controlling zoonotic diseases like Monkeypox, which has seen increased incidence due to human factors rather than viral changes. Vaccination and diagnostic testing are key to managing such diseases. Neglected tropical diseases (NTDs) are a major public health issue, particularly in low-income communities. The One Health approach is important for understanding and controlling these diseases, as they are often linked to environmental and social factors. For example, Chagas disease is transmitted by triatomine bugs and can be spread through blood transfusion. The One Health approach considers the role of the environment and social conditions in disease transmission. Antimicrobial resistance is a significant threat, driven by the misuse of antibiotics in human and veterinary medicine. The One Health approach is essential for addressing this issue, as resistance can spread through the environment and food chain. The overuse of antibiotics in agriculture also contributes to the problem, with many countries using antibiotics for growth promotion and disease prevention. Food safety is another area where the One Health approach is important. Contaminated food can lead to foodborne illnesses, and the One Health approach considers the role of animals and the environment in food safety. For example, outbreaks of Trichinella have been linked to the consumption of undercooked meat. The One Health approach also considers the impact of urbanization and lifestyle on the gut microbiome, which can affect health. In summary, the One Health approach is essential for addressingThe One Health Concept emphasizes the interconnectedness of human, animal, and environmental health. It recognizes that human health is closely linked to the health of other animals and their environments. The concept has gained traction in response to global challenges such as the COVID-19 pandemic and climate change, prompting international cooperation to address health and welfare issues. The United Nations Sustainable Development Goals include targets related to health, clean water, climate action, and ecosystem sustainability. The One Health Quadripartite, comprising WHO, WOAH, FAO, and UNEP, focuses on six areas: laboratory services, zoonotic disease control, neglected tropical diseases, antimicrobial resistance, food safety, and environmental health. Biomedical and clinical scientists play a key role in applying the One Health approach to healthcare in the 21st century. Laboratory services are crucial for diagnosing infectious diseases, as symptoms can be non-specific. The One Health approach encourages collaboration between medical and veterinary scientists to develop testing protocols. For example, Leishmania parasites affect both humans and animals, and PCR is a valuable diagnostic tool. Laboratory services also support disease surveillance, with many countries collecting data on human pathogens. Similar systems exist for animal diseases, with regional and international monitoring systems in place. Zoonotic diseases require a One Health approach to understand transmission dynamics and control. For example, rabies control in Europe led to an increase in fox populations, which are hosts for Echinococcus multilocularis, a parasite that can infect humans. The One Health approach is essential for controlling zoonotic diseases like Monkeypox, which has seen increased incidence due to human factors rather than viral changes. Vaccination and diagnostic testing are key to managing such diseases. Neglected tropical diseases (NTDs) are a major public health issue, particularly in low-income communities. The One Health approach is important for understanding and controlling these diseases, as they are often linked to environmental and social factors. For example, Chagas disease is transmitted by triatomine bugs and can be spread through blood transfusion. The One Health approach considers the role of the environment and social conditions in disease transmission. Antimicrobial resistance is a significant threat, driven by the misuse of antibiotics in human and veterinary medicine. The One Health approach is essential for addressing this issue, as resistance can spread through the environment and food chain. The overuse of antibiotics in agriculture also contributes to the problem, with many countries using antibiotics for growth promotion and disease prevention. Food safety is another area where the One Health approach is important. Contaminated food can lead to foodborne illnesses, and the One Health approach considers the role of animals and the environment in food safety. For example, outbreaks of Trichinella have been linked to the consumption of undercooked meat. The One Health approach also considers the impact of urbanization and lifestyle on the gut microbiome, which can affect health. In summary, the One Health approach is essential for addressing