16 February 2012 | Jonas F Ludvigsson, Daniel A Leffler, Julio C Bai, Federico Biagi, Alessio Fasano, Peter H R Green, Marios Hadjivassiliou, Katri Kaukinen, Ciaran P Kelly, Jonathan N Leonard, Knut Erik Aslaksen Lundin, Joseph A Murray, David S Sanders, Marjorie M Walker, Fabiana Zingone, Carolina Ciacci
The paper presents the Oslo definitions for terms related to coeliac disease (CD) and gluten. A multidisciplinary task force of 16 physicians from seven countries reviewed the literature and defined terms such as "CD," "asymptomatic CD," "classical CD," "gluten-related disorders," and others. The definitions aim to improve communication and consistency in research and clinical practice. Key points include:
- CD is defined as a chronic small intestinal immune-mediated enteropathy triggered by dietary gluten in genetically predisposed individuals.
- Classical CD presents with signs and symptoms of malabsorption, such as diarrhea, steatorrhea, weight loss, or growth failure.
- Gluten-related disorders encompass all conditions triggered by gluten ingestion.
- The term "gluten intolerance" is discouraged due to its non-specificity and contradictions.
- "Subclinical CD" is defined as disease below the threshold of clinical detection.
- "Refractory CD" refers to persistent or recurrent malabsorptive symptoms despite a strict gluten-free diet.
- "Latent CD" is discouraged in favor of "potential CD," which describes individuals with normal mucosa but increased risk of developing CD.
- "CD autoimmunity" is defined as positive TTG or EMA on at least two occasions.
- "Genetically at risk of CD" refers to family members with HLA-DO2 or HLA-DO8 who are at increased risk of developing CD.
- "Gliadin-specific antibodies" are used for diagnostic purposes and measurement of gluten in foods.
- "Coeliac disease serology" includes various antibody tests for CD diagnosis.
- "Gluten ataxia" is defined as idiopathic sporadic ataxia with positive serum antigliadin antibodies.
- "Dermatitis herpetiformis" is a cutaneous manifestation of CD characterized by herpetiform clusters of pruritic urticarial papules and vesicles.
These definitions aim to standardize terminology and improve the understanding and management of CD and related disorders.The paper presents the Oslo definitions for terms related to coeliac disease (CD) and gluten. A multidisciplinary task force of 16 physicians from seven countries reviewed the literature and defined terms such as "CD," "asymptomatic CD," "classical CD," "gluten-related disorders," and others. The definitions aim to improve communication and consistency in research and clinical practice. Key points include:
- CD is defined as a chronic small intestinal immune-mediated enteropathy triggered by dietary gluten in genetically predisposed individuals.
- Classical CD presents with signs and symptoms of malabsorption, such as diarrhea, steatorrhea, weight loss, or growth failure.
- Gluten-related disorders encompass all conditions triggered by gluten ingestion.
- The term "gluten intolerance" is discouraged due to its non-specificity and contradictions.
- "Subclinical CD" is defined as disease below the threshold of clinical detection.
- "Refractory CD" refers to persistent or recurrent malabsorptive symptoms despite a strict gluten-free diet.
- "Latent CD" is discouraged in favor of "potential CD," which describes individuals with normal mucosa but increased risk of developing CD.
- "CD autoimmunity" is defined as positive TTG or EMA on at least two occasions.
- "Genetically at risk of CD" refers to family members with HLA-DO2 or HLA-DO8 who are at increased risk of developing CD.
- "Gliadin-specific antibodies" are used for diagnostic purposes and measurement of gluten in foods.
- "Coeliac disease serology" includes various antibody tests for CD diagnosis.
- "Gluten ataxia" is defined as idiopathic sporadic ataxia with positive serum antigliadin antibodies.
- "Dermatitis herpetiformis" is a cutaneous manifestation of CD characterized by herpetiform clusters of pruritic urticarial papules and vesicles.
These definitions aim to standardize terminology and improve the understanding and management of CD and related disorders.