The PRISMA 2020 statement is an updated guideline for reporting systematic reviews, replacing the 2009 version. It reflects advancements in systematic review methods, including improved ways to identify, select, appraise, and synthesize studies. The guideline includes a 27-item checklist, an expanded checklist with detailed reporting recommendations, and a PRISMA 2020 abstract checklist. It also provides revised flow diagrams for original and updated reviews. The statement aims to ensure transparency, completeness, and accuracy in reporting systematic reviews, which are essential for informing research, policy, and clinical practice. The PRISMA 2020 checklist includes seven sections with 27 items, some of which have sub-items. It is applicable to reviews of health interventions, as well as other interventions and non-interventional studies. The checklist is intended for use in both synthesized and non-synthesized reviews, including mixed-methods reviews. The statement emphasizes the importance of reporting the certainty of evidence and the implications of findings for decision-making. It also includes a glossary of terms and references to other reporting guidelines where relevant. The PRISMA 2020 statement is not intended to guide the conduct of systematic reviews but to ensure that all recommended information is captured in the reporting. It should not be used to assess the quality of systematic reviews, as other tools exist for this purpose. The statement also notes that a separate statement (PRISMA-P) is available for reporting review protocols. The PRISMA 2020 statement is intended to be used early in the writing process to ensure all items are addressed. It includes fillable templates and a web application for completing the checklist. The statement is available in multiple languages and encourages journal editors and publishers to promote its use. The PRISMA 2020 statement is supported by a team of researchers and is endorsed by numerous journals and organizations. The statement was developed through a collaborative process involving systematic review methodologists, journal editors, and other stakeholders. It was informed by a review of existing literature and surveys of experts in the field. The statement includes new items and revisions to existing ones to reflect current practices in systematic review reporting. It also includes a box summarizing the key changes from the 2009 statement. The PRISMA 2020 statement is intended to improve the quality and transparency of systematic reviews, facilitating evidence-based decision-making.The PRISMA 2020 statement is an updated guideline for reporting systematic reviews, replacing the 2009 version. It reflects advancements in systematic review methods, including improved ways to identify, select, appraise, and synthesize studies. The guideline includes a 27-item checklist, an expanded checklist with detailed reporting recommendations, and a PRISMA 2020 abstract checklist. It also provides revised flow diagrams for original and updated reviews. The statement aims to ensure transparency, completeness, and accuracy in reporting systematic reviews, which are essential for informing research, policy, and clinical practice. The PRISMA 2020 checklist includes seven sections with 27 items, some of which have sub-items. It is applicable to reviews of health interventions, as well as other interventions and non-interventional studies. The checklist is intended for use in both synthesized and non-synthesized reviews, including mixed-methods reviews. The statement emphasizes the importance of reporting the certainty of evidence and the implications of findings for decision-making. It also includes a glossary of terms and references to other reporting guidelines where relevant. The PRISMA 2020 statement is not intended to guide the conduct of systematic reviews but to ensure that all recommended information is captured in the reporting. It should not be used to assess the quality of systematic reviews, as other tools exist for this purpose. The statement also notes that a separate statement (PRISMA-P) is available for reporting review protocols. The PRISMA 2020 statement is intended to be used early in the writing process to ensure all items are addressed. It includes fillable templates and a web application for completing the checklist. The statement is available in multiple languages and encourages journal editors and publishers to promote its use. The PRISMA 2020 statement is supported by a team of researchers and is endorsed by numerous journals and organizations. The statement was developed through a collaborative process involving systematic review methodologists, journal editors, and other stakeholders. It was informed by a review of existing literature and surveys of experts in the field. The statement includes new items and revisions to existing ones to reflect current practices in systematic review reporting. It also includes a box summarizing the key changes from the 2009 statement. The PRISMA 2020 statement is intended to improve the quality and transparency of systematic reviews, facilitating evidence-based decision-making.