The PRISMA 2020 statement is an updated guideline for reporting systematic reviews, replacing the 2009 version. It reflects advances in systematic review methodology and terminology, including new methods for identifying, selecting, appraising, and synthesizing studies. The guideline includes a 27-item checklist, an expanded checklist with detailed reporting recommendations, an abstract checklist, and revised flow diagrams. The PRISMA 2020 statement aims to improve the transparency, completeness, and accuracy of systematic reviews, benefiting authors, editors, peer reviewers, and users of reviews such as guideline developers, policymakers, healthcare providers, and patients. The development process involved literature reviews, surveys, and an in-person meeting. The guideline is intended for systematic reviews of health interventions, mixed-methods reviews, and both original and updated reviews. It is not intended to guide review conduct or assess methodological quality but to enhance transparency and replicability. The PRISMA 2020 statement is expected to facilitate evidence-based decision-making and improve the overall quality of systematic reviews.The PRISMA 2020 statement is an updated guideline for reporting systematic reviews, replacing the 2009 version. It reflects advances in systematic review methodology and terminology, including new methods for identifying, selecting, appraising, and synthesizing studies. The guideline includes a 27-item checklist, an expanded checklist with detailed reporting recommendations, an abstract checklist, and revised flow diagrams. The PRISMA 2020 statement aims to improve the transparency, completeness, and accuracy of systematic reviews, benefiting authors, editors, peer reviewers, and users of reviews such as guideline developers, policymakers, healthcare providers, and patients. The development process involved literature reviews, surveys, and an in-person meeting. The guideline is intended for systematic reviews of health interventions, mixed-methods reviews, and both original and updated reviews. It is not intended to guide review conduct or assess methodological quality but to enhance transparency and replicability. The PRISMA 2020 statement is expected to facilitate evidence-based decision-making and improve the overall quality of systematic reviews.