This review article explores the pharmacological potential of rutin, a flavonoid found in various plants such as tea leaves, apples, and buckwheat. Rutin has been extensively studied for its diverse therapeutic properties, including antioxidant, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective, and cardioprotective effects. The article highlights the current understanding of rutin's health-promoting effects, safety pharmacology, and structure-activity relationship. Key areas of focus include its actions on the central nervous system, analgesic and antiarthritic activities, endocrine system, cardiovascular system, gastrointestinal system, respiratory system, bones, eye, excretory system, reproductive system, anticancer effects, chemotherapeutic activity, hair, skin, immune effects, body strength, organ protective effects, wound healing, and radio modulatory effects. The review also discusses rutin's role in drug interaction and its potential as a radioprotector. Overall, rutin is recognized as a vital phytochemical with significant therapeutic potential, warranting further extensive study to establish its safety profile in humans.This review article explores the pharmacological potential of rutin, a flavonoid found in various plants such as tea leaves, apples, and buckwheat. Rutin has been extensively studied for its diverse therapeutic properties, including antioxidant, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective, and cardioprotective effects. The article highlights the current understanding of rutin's health-promoting effects, safety pharmacology, and structure-activity relationship. Key areas of focus include its actions on the central nervous system, analgesic and antiarthritic activities, endocrine system, cardiovascular system, gastrointestinal system, respiratory system, bones, eye, excretory system, reproductive system, anticancer effects, chemotherapeutic activity, hair, skin, immune effects, body strength, organ protective effects, wound healing, and radio modulatory effects. The review also discusses rutin's role in drug interaction and its potential as a radioprotector. Overall, rutin is recognized as a vital phytochemical with significant therapeutic potential, warranting further extensive study to establish its safety profile in humans.