The article explores the intricate relationship between the circadian rhythm and cancer, highlighting how disruptions to this internal clock can contribute to tumor development and influence cancer progression. The circadian clock, regulated by genes and environmental cues, plays a crucial role in maintaining physiological homeostasis and coordinating various biological processes. Disruptions to this rhythm, often caused by factors such as irregular sleep patterns, exposure to artificial light, and jet lag, can lead to hormonal imbalances, immune system disturbances, and increased risk of cancer. The article discusses the molecular mechanisms underlying these disruptions, including the role of clock genes, melatonin, and the immune system. It also reviews the impact of circadian rhythm disruptions on different diseases, emphasizing their association with neurodegenerative disorders, mood disorders, metabolic disorders, and cardiovascular diseases. The article concludes by emphasizing the importance of maintaining healthy circadian rhythms through proper sleep habits and minimizing disruptions to prevent and treat cancer.The article explores the intricate relationship between the circadian rhythm and cancer, highlighting how disruptions to this internal clock can contribute to tumor development and influence cancer progression. The circadian clock, regulated by genes and environmental cues, plays a crucial role in maintaining physiological homeostasis and coordinating various biological processes. Disruptions to this rhythm, often caused by factors such as irregular sleep patterns, exposure to artificial light, and jet lag, can lead to hormonal imbalances, immune system disturbances, and increased risk of cancer. The article discusses the molecular mechanisms underlying these disruptions, including the role of clock genes, melatonin, and the immune system. It also reviews the impact of circadian rhythm disruptions on different diseases, emphasizing their association with neurodegenerative disorders, mood disorders, metabolic disorders, and cardiovascular diseases. The article concludes by emphasizing the importance of maintaining healthy circadian rhythms through proper sleep habits and minimizing disruptions to prevent and treat cancer.