The article explores the role of ergonomics and human factors in sustainable manufacturing, emphasizing their critical importance in achieving efficient, safe, and sustainable industrial practices. Ergonomics, defined as the science of designing tools, tasks, and environments to fit human capabilities, is essential for optimizing worker performance, safety, and well-being while promoting sustainability. Human factors, a subset of ergonomics, focus on the psychological and physiological aspects of human interaction with systems, ensuring that design and processes align with human needs and capabilities. The integration of human factors and ergonomics into sustainable manufacturing is vital for addressing ecological, social, and economic challenges, as well as enhancing productivity and quality of life. The review highlights the growing importance of ergonomics in Industry 4.0, where advanced technologies such as the Internet of Things (IoT), digital twins, and artificial intelligence are being integrated to improve human-centered design and manufacturing processes. Key concepts such as ergoecology, eco-ergonomics, and green ergonomics are discussed, emphasizing their role in promoting sustainable practices. The article also discusses the challenges of incorporating sustainability into manufacturing, including ecological and social effectiveness, economic viability, and management issues. Bibliometric and PRISMA analyses are used to identify the literature base for ergonomics in sustainable manufacturing, revealing a significant growth in research over the past decade. The study highlights the importance of interdisciplinary approaches, combining ergonomics with business management, organizational strategy, and sustainable development. The review also discusses the role of human factors in addressing issues such as workplace well-being, safety, and the integration of diverse cultural perspectives in design and production. The article emphasizes the need for a paradigm shift in ergonomics to better align with sustainability goals, incorporating human-centered design principles and considering the broader implications of ergonomic interventions on both individual and organizational levels. The integration of ergonomics into sustainable manufacturing is seen as a key factor in achieving long-term environmental and social benefits, ensuring that industrial practices are not only efficient but also responsible and sustainable. Overall, the review underscores the critical role of ergonomics and human factors in shaping the future of sustainable manufacturing.The article explores the role of ergonomics and human factors in sustainable manufacturing, emphasizing their critical importance in achieving efficient, safe, and sustainable industrial practices. Ergonomics, defined as the science of designing tools, tasks, and environments to fit human capabilities, is essential for optimizing worker performance, safety, and well-being while promoting sustainability. Human factors, a subset of ergonomics, focus on the psychological and physiological aspects of human interaction with systems, ensuring that design and processes align with human needs and capabilities. The integration of human factors and ergonomics into sustainable manufacturing is vital for addressing ecological, social, and economic challenges, as well as enhancing productivity and quality of life. The review highlights the growing importance of ergonomics in Industry 4.0, where advanced technologies such as the Internet of Things (IoT), digital twins, and artificial intelligence are being integrated to improve human-centered design and manufacturing processes. Key concepts such as ergoecology, eco-ergonomics, and green ergonomics are discussed, emphasizing their role in promoting sustainable practices. The article also discusses the challenges of incorporating sustainability into manufacturing, including ecological and social effectiveness, economic viability, and management issues. Bibliometric and PRISMA analyses are used to identify the literature base for ergonomics in sustainable manufacturing, revealing a significant growth in research over the past decade. The study highlights the importance of interdisciplinary approaches, combining ergonomics with business management, organizational strategy, and sustainable development. The review also discusses the role of human factors in addressing issues such as workplace well-being, safety, and the integration of diverse cultural perspectives in design and production. The article emphasizes the need for a paradigm shift in ergonomics to better align with sustainability goals, incorporating human-centered design principles and considering the broader implications of ergonomic interventions on both individual and organizational levels. The integration of ergonomics into sustainable manufacturing is seen as a key factor in achieving long-term environmental and social benefits, ensuring that industrial practices are not only efficient but also responsible and sustainable. Overall, the review underscores the critical role of ergonomics and human factors in shaping the future of sustainable manufacturing.