This review explores the role of ergonomics and human factors in sustainable manufacturing. Ergonomics is crucial for improving industrial efficiency and work culture, and is essential for achieving sustainable manufacturing. It involves designing tools, tasks, machines, systems, jobs, and settings to ensure efficient, safe, and successful human usage. Ergonomics considers human behavior, abilities, and limitations to optimize worker safety, health, and comfort, as well as enhance efficiency and productivity. The review outlines significant advancements in preventing ergonomic problems during the design stage of the manufacturing process to achieve sustainability. Bibliometric analysis is used to identify the literature base for ergonomics. Various methods are required to organize existing processes and technologies to maximize the benefits of ergonomics and integrate sustainable practices. Human-centered design identifies problems and aligns the output with the intended objectives of sustainability. The goal of human factors and ergonomics is to successfully integrate people into systems and develop the manufacturing processes around the well-being of workers and sustainability principles. Ergoecology, eco-ergonomics, and green ergonomics are frequently used for sustainable manufacturing. Achieving sustainability in manufacturing is not possible without considering human ergonomics. Ergonomists frequently research management, planning, and other topics to increase the efficiency of the manufacturing process. Efficient worker performance and quality of life can be enhanced through work design, management, and organizational ergonomics. Human ergonomics relates sustainability with cognitive variables such as situational awareness, human reliability, and decision-making abilities. This review explains the role of human factors and ergonomics for sustainable manufacturing. Keywords: ergonomics; Industry 4.0; human factors; sustainability; manufacturing. The review discusses the importance of ergonomics and human factors in sustainable manufacturing, explaining how optimizing human factors enhances productivity. It also discusses how ergonomics and its relationship with workplace well-being, sustainability, and cross-cultural differences are discussed, leading to the components of sustainability and the challenges in implementing them in a workplace. The review incorporates bibliometric and PRISMA analysis to further cement the importance and role of ergonomics in Industry 4.0 based on the keywords. After this, the scope and definition of human factors are explained, and the relationship of human factors with business management, organizational strategy, sustainable developments, and human–system interactions is discussed. The shift in global work culture, demographic shifts, and social interactions are explained. Furthermore, the importance of sustainability in Industry 4.0 and its role in additive manufacturing in combination with information technology are discussed. In the end, how ergonomics can efficiently design jobs with human workability, employability, and the integration of research hand innovation, with the changing landscape of the manufacturing industry, is discussed. The review outlines the importance of ergonomics and human factors in sustainable manufacturing. This review starts with an explanation of human factors and the role these factors play in ergonomics. Ergonomics is further categorized toThis review explores the role of ergonomics and human factors in sustainable manufacturing. Ergonomics is crucial for improving industrial efficiency and work culture, and is essential for achieving sustainable manufacturing. It involves designing tools, tasks, machines, systems, jobs, and settings to ensure efficient, safe, and successful human usage. Ergonomics considers human behavior, abilities, and limitations to optimize worker safety, health, and comfort, as well as enhance efficiency and productivity. The review outlines significant advancements in preventing ergonomic problems during the design stage of the manufacturing process to achieve sustainability. Bibliometric analysis is used to identify the literature base for ergonomics. Various methods are required to organize existing processes and technologies to maximize the benefits of ergonomics and integrate sustainable practices. Human-centered design identifies problems and aligns the output with the intended objectives of sustainability. The goal of human factors and ergonomics is to successfully integrate people into systems and develop the manufacturing processes around the well-being of workers and sustainability principles. Ergoecology, eco-ergonomics, and green ergonomics are frequently used for sustainable manufacturing. Achieving sustainability in manufacturing is not possible without considering human ergonomics. Ergonomists frequently research management, planning, and other topics to increase the efficiency of the manufacturing process. Efficient worker performance and quality of life can be enhanced through work design, management, and organizational ergonomics. Human ergonomics relates sustainability with cognitive variables such as situational awareness, human reliability, and decision-making abilities. This review explains the role of human factors and ergonomics for sustainable manufacturing. Keywords: ergonomics; Industry 4.0; human factors; sustainability; manufacturing. The review discusses the importance of ergonomics and human factors in sustainable manufacturing, explaining how optimizing human factors enhances productivity. It also discusses how ergonomics and its relationship with workplace well-being, sustainability, and cross-cultural differences are discussed, leading to the components of sustainability and the challenges in implementing them in a workplace. The review incorporates bibliometric and PRISMA analysis to further cement the importance and role of ergonomics in Industry 4.0 based on the keywords. After this, the scope and definition of human factors are explained, and the relationship of human factors with business management, organizational strategy, sustainable developments, and human–system interactions is discussed. The shift in global work culture, demographic shifts, and social interactions are explained. Furthermore, the importance of sustainability in Industry 4.0 and its role in additive manufacturing in combination with information technology are discussed. In the end, how ergonomics can efficiently design jobs with human workability, employability, and the integration of research hand innovation, with the changing landscape of the manufacturing industry, is discussed. The review outlines the importance of ergonomics and human factors in sustainable manufacturing. This review starts with an explanation of human factors and the role these factors play in ergonomics. Ergonomics is further categorized to