Oxidative stress and antioxidants play a critical role in liver diseases. The liver is particularly vulnerable to oxidative stress due to its metabolic functions, and excessive reactive oxygen and nitrogen species can cause tissue damage. Factors such as alcohol, drugs, environmental pollutants, and radiation can induce oxidative stress, leading to liver diseases like alcoholic liver disease and non-alcoholic steatohepatitis. Antioxidants, including natural compounds from plants and foods, have strong antioxidant and anti-inflammatory properties and are considered effective in preventing and treating liver diseases. Animal studies suggest that antioxidants can reduce oxidative stress and liver damage, while clinical trials have shown some benefits of antioxidants like vitamin E, N-acetylcysteine, and silymarin in liver disease treatment. However, the effectiveness of antioxidants in clinical settings remains uncertain due to limited sample sizes and treatment durations. Antioxidants such as betulinic acid, raxofelast, and berberine have shown promise in protecting the liver from oxidative damage. Additionally, melatonin has been found to have strong antioxidant properties and may be more effective than vitamin E and C in certain liver diseases. Current clinical trials are exploring the use of antioxidants in liver disease treatment, with some compounds like silymarin, metadoxine, and N-acetylcysteine being studied for their potential in treating non-alcoholic fatty liver disease and alcoholic liver disease. Despite promising results, further research is needed to fully understand the role of antioxidants in liver disease prevention and treatment.Oxidative stress and antioxidants play a critical role in liver diseases. The liver is particularly vulnerable to oxidative stress due to its metabolic functions, and excessive reactive oxygen and nitrogen species can cause tissue damage. Factors such as alcohol, drugs, environmental pollutants, and radiation can induce oxidative stress, leading to liver diseases like alcoholic liver disease and non-alcoholic steatohepatitis. Antioxidants, including natural compounds from plants and foods, have strong antioxidant and anti-inflammatory properties and are considered effective in preventing and treating liver diseases. Animal studies suggest that antioxidants can reduce oxidative stress and liver damage, while clinical trials have shown some benefits of antioxidants like vitamin E, N-acetylcysteine, and silymarin in liver disease treatment. However, the effectiveness of antioxidants in clinical settings remains uncertain due to limited sample sizes and treatment durations. Antioxidants such as betulinic acid, raxofelast, and berberine have shown promise in protecting the liver from oxidative damage. Additionally, melatonin has been found to have strong antioxidant properties and may be more effective than vitamin E and C in certain liver diseases. Current clinical trials are exploring the use of antioxidants in liver disease treatment, with some compounds like silymarin, metadoxine, and N-acetylcysteine being studied for their potential in treating non-alcoholic fatty liver disease and alcoholic liver disease. Despite promising results, further research is needed to fully understand the role of antioxidants in liver disease prevention and treatment.