The article discusses the role of oxidative stress and antioxidants in liver diseases. Oxidative stress, caused by excessive reactive oxygen and nitrogen species, contributes to liver injury and is involved in the progression of various liver diseases, including alcoholic liver disease and non-alcoholic steatohepatitis. The body has a complex antioxidant system to manage oxidative stress, but when this balance is disrupted, it can lead to tissue damage. Antioxidants, both enzymatic and non-enzymatic, play a crucial role in protecting against oxidative stress. Natural antioxidants found in foods and medicinal plants have shown potential in preventing and treating liver diseases by scavenging free radicals and reducing inflammation. The article reviews the mechanisms of oxidative stress in liver diseases, the factors that induce it, and the therapeutic potential of antioxidants. It also highlights the importance of further research to fully understand the role of antioxidants in liver disease prevention and treatment.The article discusses the role of oxidative stress and antioxidants in liver diseases. Oxidative stress, caused by excessive reactive oxygen and nitrogen species, contributes to liver injury and is involved in the progression of various liver diseases, including alcoholic liver disease and non-alcoholic steatohepatitis. The body has a complex antioxidant system to manage oxidative stress, but when this balance is disrupted, it can lead to tissue damage. Antioxidants, both enzymatic and non-enzymatic, play a crucial role in protecting against oxidative stress. Natural antioxidants found in foods and medicinal plants have shown potential in preventing and treating liver diseases by scavenging free radicals and reducing inflammation. The article reviews the mechanisms of oxidative stress in liver diseases, the factors that induce it, and the therapeutic potential of antioxidants. It also highlights the importance of further research to fully understand the role of antioxidants in liver disease prevention and treatment.