Pro-inflammatory cytokines play a significant role in the pathogenesis of cardiovascular disease (CVD). These cytokines, including interleukin-6 (IL-6), tumor necrosis factor (TNF) α, and interleukin-1 (IL-1) family members, are involved in various CVDs such as atherosclerosis, thrombosis, acute myocardial infarction, and ischemia-reperfusion injury. They contribute to inflammation, oxidative stress, and calcium mishandling, which are key factors in the development of heart disease. While pre-clinical and clinical evidence shows their involvement in heart conditions, the clinical utility of these findings remains unclear. This review highlights the role of pro-inflammatory cytokines in CVD, including their contributions to cardiac remodeling, different cardiomyopathies, and arrhythmias. It also discusses the shortcomings in both pathological and therapeutic aspects of these cytokines in CVD that require further research. The review covers the general characteristics of pro-inflammatory cytokines, their interactions with other pathogenic mechanisms, and their roles in specific CVDs such as ischemic heart disease, thrombosis, acute myocardial infarction, and ischemia-reperfusion injury. The study emphasizes the complex network of interactions among these cytokines and their potential as therapeutic targets in CVD.Pro-inflammatory cytokines play a significant role in the pathogenesis of cardiovascular disease (CVD). These cytokines, including interleukin-6 (IL-6), tumor necrosis factor (TNF) α, and interleukin-1 (IL-1) family members, are involved in various CVDs such as atherosclerosis, thrombosis, acute myocardial infarction, and ischemia-reperfusion injury. They contribute to inflammation, oxidative stress, and calcium mishandling, which are key factors in the development of heart disease. While pre-clinical and clinical evidence shows their involvement in heart conditions, the clinical utility of these findings remains unclear. This review highlights the role of pro-inflammatory cytokines in CVD, including their contributions to cardiac remodeling, different cardiomyopathies, and arrhythmias. It also discusses the shortcomings in both pathological and therapeutic aspects of these cytokines in CVD that require further research. The review covers the general characteristics of pro-inflammatory cytokines, their interactions with other pathogenic mechanisms, and their roles in specific CVDs such as ischemic heart disease, thrombosis, acute myocardial infarction, and ischemia-reperfusion injury. The study emphasizes the complex network of interactions among these cytokines and their potential as therapeutic targets in CVD.