The article "The Role of Vasculature and Angiogenic Strategies in Bone Regeneration" by Hye-Jeong Jang and Jeong-Kee Yoon provides a comprehensive review of the critical role of vasculature in bone regeneration and the applications of angiogenic strategies. Bone regeneration is a complex process involving various growth factors, cell types, and extracellular matrix components. The formation of a vascular network is crucial for providing essential nutrients and oxygen, promoting osteogenesis, and facilitating the interaction between bone tissue and the surrounding environment. The review highlights recent advancements in bone tissue engineering strategies that integrate vascularized bone complexes, recognizing the significant role of vasculature in bone regeneration. The article begins by examining the role of angiogenesis in bone regeneration, followed by an introduction to various in vitro and in vivo applications that have achieved accelerated bone regeneration through angiogenesis. It also identifies remaining challenges and outlines future directions for research in vascularized bone regeneration. Key topics covered include the mechanisms of bone vasculature formation, the coupling of osteogenesis and angiogenesis, and the use of angiogenic factors, cells, and gene delivery strategies to promote bone regeneration. Recent studies have focused on innovative approaches such as perfusable 3D vascular networks, hydrogels inducing angiogenesis, extracellular vesicle (EV) delivery, and three-dimensional bioprinted models. These strategies aim to create more effective and tailored healing solutions for complex bone defects. The review concludes by discussing the potential of these advancements and the need for further research to optimize therapeutic interventions in bone regeneration.The article "The Role of Vasculature and Angiogenic Strategies in Bone Regeneration" by Hye-Jeong Jang and Jeong-Kee Yoon provides a comprehensive review of the critical role of vasculature in bone regeneration and the applications of angiogenic strategies. Bone regeneration is a complex process involving various growth factors, cell types, and extracellular matrix components. The formation of a vascular network is crucial for providing essential nutrients and oxygen, promoting osteogenesis, and facilitating the interaction between bone tissue and the surrounding environment. The review highlights recent advancements in bone tissue engineering strategies that integrate vascularized bone complexes, recognizing the significant role of vasculature in bone regeneration. The article begins by examining the role of angiogenesis in bone regeneration, followed by an introduction to various in vitro and in vivo applications that have achieved accelerated bone regeneration through angiogenesis. It also identifies remaining challenges and outlines future directions for research in vascularized bone regeneration. Key topics covered include the mechanisms of bone vasculature formation, the coupling of osteogenesis and angiogenesis, and the use of angiogenic factors, cells, and gene delivery strategies to promote bone regeneration. Recent studies have focused on innovative approaches such as perfusable 3D vascular networks, hydrogels inducing angiogenesis, extracellular vesicle (EV) delivery, and three-dimensional bioprinted models. These strategies aim to create more effective and tailored healing solutions for complex bone defects. The review concludes by discussing the potential of these advancements and the need for further research to optimize therapeutic interventions in bone regeneration.