The article reviews the role of the gut microbiome and its dysbiosis in the development and progression of common skin diseases, including atopic dermatitis, psoriasis, alopecia areata, and acne. The gut microbiome, the largest endocrine organ, plays a crucial role in maintaining human homeostasis and immune function. Disruption of the gut microbiome, known as dysbiosis, can lead to adverse effects on skin health. The authors highlight the bidirectional relationship between the gut and skin, where changes in the gut microbiome can influence skin conditions and vice versa. Probiotics are discussed as a potential therapeutic approach to modulate the gut microbiome and alleviate dermatological conditions. Studies have shown that probiotics can improve symptoms and reduce the need for conventional treatments. However, more research is needed to confirm the efficacy of probiotics and fecal microbiota transplantation (FMT) in treating these skin diseases. The authors conclude that targeting the gut microbiome represents a promising future direction for treating dermatological conditions, but further studies are required to optimize dosages and combinations of probiotics and prebiotics.The article reviews the role of the gut microbiome and its dysbiosis in the development and progression of common skin diseases, including atopic dermatitis, psoriasis, alopecia areata, and acne. The gut microbiome, the largest endocrine organ, plays a crucial role in maintaining human homeostasis and immune function. Disruption of the gut microbiome, known as dysbiosis, can lead to adverse effects on skin health. The authors highlight the bidirectional relationship between the gut and skin, where changes in the gut microbiome can influence skin conditions and vice versa. Probiotics are discussed as a potential therapeutic approach to modulate the gut microbiome and alleviate dermatological conditions. Studies have shown that probiotics can improve symptoms and reduce the need for conventional treatments. However, more research is needed to confirm the efficacy of probiotics and fecal microbiota transplantation (FMT) in treating these skin diseases. The authors conclude that targeting the gut microbiome represents a promising future direction for treating dermatological conditions, but further studies are required to optimize dosages and combinations of probiotics and prebiotics.