The SWISS-MODEL Repository (SMR) is an extensive database of annotated 3D protein structure models generated by the SWISS-MODEL homology modeling pipeline. This manuscript updates recent features and functionalities, including improvements in target coverage, model quality estimates, functional annotations, and in-page visualization. SMR now offers a new update concept with regular updates of core organism models and UniProtKB-based targets, complemented by user-driven on-demand updates. The repository has implemented a REST-API and adopted an open licensing model for model coordinates, enabling bulk downloads and fostering reuse in various contexts. SMR provides access to over 400,000 high-quality models, covering nearly 20% of SwissProt/UniProtKB entries. The repository aims to bridge the gap between experimental protein structures and sequence annotations by offering a comprehensive collection of pre-computed homology models and experimental structure information for relevant model organism proteomes and other UniProtKB sequences. The continuous update policy ensures that models are based on the latest template information, and the web interface offers interactive visualization and detailed model quality assessments. SMR also supports cross-linking with UniProtKB, InterPro, STRING, and the PMP Protein Model Portal, facilitating the integration of structural and functional annotations.The SWISS-MODEL Repository (SMR) is an extensive database of annotated 3D protein structure models generated by the SWISS-MODEL homology modeling pipeline. This manuscript updates recent features and functionalities, including improvements in target coverage, model quality estimates, functional annotations, and in-page visualization. SMR now offers a new update concept with regular updates of core organism models and UniProtKB-based targets, complemented by user-driven on-demand updates. The repository has implemented a REST-API and adopted an open licensing model for model coordinates, enabling bulk downloads and fostering reuse in various contexts. SMR provides access to over 400,000 high-quality models, covering nearly 20% of SwissProt/UniProtKB entries. The repository aims to bridge the gap between experimental protein structures and sequence annotations by offering a comprehensive collection of pre-computed homology models and experimental structure information for relevant model organism proteomes and other UniProtKB sequences. The continuous update policy ensures that models are based on the latest template information, and the web interface offers interactive visualization and detailed model quality assessments. SMR also supports cross-linking with UniProtKB, InterPro, STRING, and the PMP Protein Model Portal, facilitating the integration of structural and functional annotations.