SWISS-PROT is a curated protein sequence database that aims to provide high-quality annotations, minimal redundancy, and integration with other databases. Recent developments include an expanded scope of model organisms, cross-references to additional databases, new documentation files, and the creation of TrEMBL, a computer-annotated supplement. TrEMBL consists of entries derived from the translation of all coding sequences (CDS) in the EMBL nucleotide sequence database, excluding those already in SWISS-PROT. This supplement helps manage the increasing volume of protein sequences and ensures quality standards. The database currently includes annotations for about a third of the total entries, with plans to annotate more yeast sequences in early 1997. SWISS-PROT is distributed on CD-ROM and can be accessed via FTP and the World-Wide Web through servers like ExPASy and the EBI.SWISS-PROT is a curated protein sequence database that aims to provide high-quality annotations, minimal redundancy, and integration with other databases. Recent developments include an expanded scope of model organisms, cross-references to additional databases, new documentation files, and the creation of TrEMBL, a computer-annotated supplement. TrEMBL consists of entries derived from the translation of all coding sequences (CDS) in the EMBL nucleotide sequence database, excluding those already in SWISS-PROT. This supplement helps manage the increasing volume of protein sequences and ensures quality standards. The database currently includes annotations for about a third of the total entries, with plans to annotate more yeast sequences in early 1997. SWISS-PROT is distributed on CD-ROM and can be accessed via FTP and the World-Wide Web through servers like ExPASy and the EBI.