The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000

The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000

2000, Vol. 28, No. 1 | Amos Bairoch* and Rolf Apweiler1
The article provides an overview of the SWISS-PROT protein sequence database and its supplement, TrEMBL, as of 2000. SWISS-PROT is a curated database known for its high-quality annotations, minimal redundancy, and integration with other databases. Recent developments include format and content enhancements, cross-references to additional databases, new documentation files, and improvements to TrEMBL. TrEMBL, a computer-annotated supplement, consists of entries derived from the translation of coding sequences in the EMBL Nucleotide Sequence Database, excluding those already in SWISS-PROT. The Human Proteomics Initiative (HPI) is a major project aimed at annotating all known human sequences according to SWISS-PROT standards. The article also discusses the integration of model organisms into SWISS-PROT, the importance of cross-references, and the practical aspects of using SWISS-PROT and TrEMBL, including access through web servers and CD-ROMs.The article provides an overview of the SWISS-PROT protein sequence database and its supplement, TrEMBL, as of 2000. SWISS-PROT is a curated database known for its high-quality annotations, minimal redundancy, and integration with other databases. Recent developments include format and content enhancements, cross-references to additional databases, new documentation files, and improvements to TrEMBL. TrEMBL, a computer-annotated supplement, consists of entries derived from the translation of coding sequences in the EMBL Nucleotide Sequence Database, excluding those already in SWISS-PROT. The Human Proteomics Initiative (HPI) is a major project aimed at annotating all known human sequences according to SWISS-PROT standards. The article also discusses the integration of model organisms into SWISS-PROT, the importance of cross-references, and the practical aspects of using SWISS-PROT and TrEMBL, including access through web servers and CD-ROMs.
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