This study examines global attitudes towards vaccines through a large-scale survey of 65,819 individuals across 67 countries. The survey, conducted by WIN/Gallup International in collaboration with the Vaccine Confidence Project at the London School of Hygiene & Tropical Medicine, assesses perceptions of vaccine importance, safety, effectiveness, and religious compatibility. Hierarchical models are used to analyze the relationships between individual and country-level socio-economic factors and vaccine attitudes. Key findings include: - Overall, public sentiment towards vaccinations is positive, but there is significant variability between countries and regions. - The European region reports the highest levels of skepticism about vaccine safety, with France and Bosnia & Herzegovina having the lowest levels of confidence in vaccine safety. - The Western Pacific region has the highest levels of religious incompatibility with vaccines. - Older age groups (65+) and Roman Catholics are more likely to have positive views on vaccines. - Countries with higher levels of education and better access to health services tend to have lower rates of positive sentiment, suggesting an inverse relationship between vaccine confidence and education. The study emphasizes the importance of regular monitoring of vaccine attitudes and local immunization rates to identify populations with declining confidence and to inform interventions to prevent adverse public health outcomes.This study examines global attitudes towards vaccines through a large-scale survey of 65,819 individuals across 67 countries. The survey, conducted by WIN/Gallup International in collaboration with the Vaccine Confidence Project at the London School of Hygiene & Tropical Medicine, assesses perceptions of vaccine importance, safety, effectiveness, and religious compatibility. Hierarchical models are used to analyze the relationships between individual and country-level socio-economic factors and vaccine attitudes. Key findings include: - Overall, public sentiment towards vaccinations is positive, but there is significant variability between countries and regions. - The European region reports the highest levels of skepticism about vaccine safety, with France and Bosnia & Herzegovina having the lowest levels of confidence in vaccine safety. - The Western Pacific region has the highest levels of religious incompatibility with vaccines. - Older age groups (65+) and Roman Catholics are more likely to have positive views on vaccines. - Countries with higher levels of education and better access to health services tend to have lower rates of positive sentiment, suggesting an inverse relationship between vaccine confidence and education. The study emphasizes the importance of regular monitoring of vaccine attitudes and local immunization rates to identify populations with declining confidence and to inform interventions to prevent adverse public health outcomes.