2018 | Mitchell M. Levy*, Laura E. Evans2 and Andrew Rhodes3
The "sepsis bundle" has been a cornerstone of the Surviving Sepsis Campaign (SSC) since its inception in 2004, with the bundle elements designed to be updated based on new evidence. The 2018 update combines the 3-hour and 6-hour bundles into a single "hour-1 bundle," emphasizing immediate resuscitation and management. This bundle includes measures such as measuring lactate levels, obtaining blood cultures before antibiotics, administering broad-spectrum antibiotics, starting rapid fluid resuscitation for hypotension or elevated lactate, and applying vasopressors if necessary. The hour-1 bundle is intended to be initiated within the first hour of presentation and is based on the 2016 SSC guidelines. The bundle has been adopted by various health organizations for mandated public reporting, and its implementation has been shown to improve survival rates in patients with sepsis and septic shock. The authors emphasize the importance of early identification and immediate management of sepsis as a medical emergency to improve outcomes.The "sepsis bundle" has been a cornerstone of the Surviving Sepsis Campaign (SSC) since its inception in 2004, with the bundle elements designed to be updated based on new evidence. The 2018 update combines the 3-hour and 6-hour bundles into a single "hour-1 bundle," emphasizing immediate resuscitation and management. This bundle includes measures such as measuring lactate levels, obtaining blood cultures before antibiotics, administering broad-spectrum antibiotics, starting rapid fluid resuscitation for hypotension or elevated lactate, and applying vasopressors if necessary. The hour-1 bundle is intended to be initiated within the first hour of presentation and is based on the 2016 SSC guidelines. The bundle has been adopted by various health organizations for mandated public reporting, and its implementation has been shown to improve survival rates in patients with sepsis and septic shock. The authors emphasize the importance of early identification and immediate management of sepsis as a medical emergency to improve outcomes.