The UK Biobank is a prospective cohort study that collects deep genetic and phenotypic data from approximately 500,000 individuals aged 40 to 69 across the United Kingdom. The resource is unique in its size and scope, offering a rich variety of phenotypic and health-related information, including biological measurements, lifestyle indicators, biomarkers, and imaging data. Genome-wide genotype data have been collected for all participants, providing opportunities for discovering new genetic associations and understanding the genetic basis of complex traits. The centralized analysis of genetic data includes quality control, population structure and relatedness analysis, haplotype estimation, and genotype imputation, increasing the number of testable variants to around 96 million. Classical allelic variation at 11 human leukocyte antigen (HLA) genes was imputed, recovering signals of known associations between HLA alleles and diseases. The UK Biobank's genetic data have facilitated numerous studies, and the resource continues to grow with the addition of more phenotypic information. The availability of full genetic data is expected to further enhance research in human biology and disease.The UK Biobank is a prospective cohort study that collects deep genetic and phenotypic data from approximately 500,000 individuals aged 40 to 69 across the United Kingdom. The resource is unique in its size and scope, offering a rich variety of phenotypic and health-related information, including biological measurements, lifestyle indicators, biomarkers, and imaging data. Genome-wide genotype data have been collected for all participants, providing opportunities for discovering new genetic associations and understanding the genetic basis of complex traits. The centralized analysis of genetic data includes quality control, population structure and relatedness analysis, haplotype estimation, and genotype imputation, increasing the number of testable variants to around 96 million. Classical allelic variation at 11 human leukocyte antigen (HLA) genes was imputed, recovering signals of known associations between HLA alleles and diseases. The UK Biobank's genetic data have facilitated numerous studies, and the resource continues to grow with the addition of more phenotypic information. The availability of full genetic data is expected to further enhance research in human biology and disease.